Estrogen receptor beta and ovarian cancer: a key to pathogenesis and response to therapy. Arch Gynecol Obstet. 2016; 293(6):1161-8.Estrogen receptor beta and ovarian cancer:a key to pathogenesis and response to therapy. Kyriakidis I,Papaioannidou P. Archives of Gynecology and Obstetrics . ...
An experimental drug, BHPI, binds to the estrogen receptor and disrupts the growth of cancer cells. Credit: Neal Andruska An experimental drug rapidly shrinks most tumors in a mouse model of human breast cancer, researchers report in theProceedings of the National Academy of Sciences. When mice ...
Endocrine therapy (ET) is an effective first-line therapy for women with estrogen receptor-positive (ER + ) breast cancers. While both ionizing radiation (RT) and ET are used for the treatment of women with ER+ breast cancer, the most effective
Materials and methods Cell lines and recombinant AAV vectors The human ovarian cancer cell lines OV-3, SKOV-3ip, and OVCAR-3 were purchased from ATCC (Manassas, VA, USA). OVCAR-3 and SKOV-3ip were estrogen receptor α and β positive. The transformed human embryo kidney (HEK)- 293 and...
Theestrogen receptor(ER) is an important driver in the proliferation, tumorigenesis, and progression of breast cancers, and targeting ER signaling at different levels is a successful strategy in the control ofhormone receptorpositive (HR+) breast cancer.Endocrine therapyhas been the treatment of choic...
Seventy-one percent of all the specimens contained estrogen and progestin receptors (3 or more and 6 or more fmol/mg cytosol protein, respectively, receptor-positive group), whereas 10% of the tumors were receptor-negative. Primary epithelial ovarian carcinomas were more often receptor-positive (...
Estrogen receptor (ER) expression is the main indicator of potential responses to endocrine therapy (ET), and approximately 70% of human breast cancers (BCs) are hormone-dependent and ER-positive. The introduction of adjuvant systemic therapy led to a significant improvement in post-surgical surviva...
Estrogen receptor (ER) and progesterone receptor (PR) facilitate the effects of estrogen and progesterone on proliferation and apoptosis of ovarian cancer cells10, but using hormone as a treatment for ovarian cancer has not yet been widely recommended. Ovarian cancer usually has a relatively poor ...
Estrogen, Ovarian Cancer Link ExpandedSusan Okie
Estrogen-related receptor alpha (ERRα), which shares structural similarities with estrogen receptors, is associated with tumor progression in endometrial cancer, but little is known about the detailed underlying mechanism. We investigated whether ERRα, in cooperation with peroxisome proliferator-activated...