Breast NeoplasmsReceptors, EstrogenTranscription, Genetic雄激素类乳腺肿瘤受体, 雌激素转录, 遗传Little is known of the underlying biology of estrogen receptor-negative, progesterone receptor-negative (ER(-)/PR(-)) breast cancer (BC), and few targeted therapies are available. Clinical heterogeneity of ...
Estrogen receptor (ER) and progesterone receptor (PR) testing are performed in the evaluation of breast cancer. While the clinical utility of ER as a predictive biomarker to identify patients likely to benefit from hormonal therapy is well-established, t
More than 10 years have passed since the discovery of the second estrogen receptor, estrogen receptor β (ERβ). It is now evident that ERα is not the only ER in breast cancer cells; in fact, ERβ is expressed in the majority of breast cancers although at lower levels than in the no...
Article Open access 08 November 2022 Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis Article 21 September 2020 CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer Article Open access 16 April 2020 Introduction...
Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between br
Vanderlaag K, Su Y, Frankel AE, Grage H, Smith R, III, Khan S, Safe S: 1,1- Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. Breast Cancer Res Treat 2008, 109:273-283...
Molecular dependence of estrogen receptor-negative breast cancer on a Notch-survivin signaling axis.(Report)BarrettLee, Peter
Aminoglutethimide (AG) is an effective chemical ablative form of therapy for metastatic breast cancer in postmenopausal women. Estrogen receptor (ER) status in breast cancer is useful in predicting the response to the hormonal treatments. Of 134 postmenopausal metastatic breast cancer patients treated...
estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. ...
(a) Total cell lysates from breast cancer cells were subjected to Western blot analysis for expression of BCAR3 and p130Cas. ER-, Estrogen receptor–negative; ER+, Estrogen receptor–positive. (b) MDA-MB-231 cells were transfected with a pool of two BCAR3 small interfering RNAs (siRNAs; ...