ER-mitochondria tethering by PDZD 8regulates Ca (2+)dynamics in mammalian neurons. Hirabayashi Y,Kwon SK,Paek H.et al. Science . 2017Hirabayashi Y, Kwon S-K, Paek H, Pernice WM, Paul MA, Lee J, Erfani P, Raczkowski A, Petrey DS, Pon LA, Polleux F (2017) ER-mitochondria ...
et al. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 325, 477–481 (2009). Article CAS PubMed PubMed Central Google Scholar Kornmann, B. The molecular hug between the ER and the mitochondria. Curr. Opin. Cell Biol. 25, 443–448 (2013). Article ...
Another MAM protein, mitofusin 2 (MFN2), has also been proposed as a tethering complex by establishing homo- and heterotypic interactions with mitochondrial MFN1/220. However, the role of MFN2 as an ER–mitochondria tether has been challenged as several recent studies from different laboratories h...
In agreement with the latter, it has been demonstrated that overexpression of the FAD-linked PS2 mutant leads to an increase in the generation of cytosolic Ca2+ hot spots, ER–mitochondria tethering, and mitochondrial Ca2+ uptake [189]. In addition, the brains of patients with AD and in AD...
(C) Mitochondrial morphology is regulated by different MAM-resident proteins: MFN1/2 are involved in the mitochondrial fusion mechanism but also in ER-mitochondria tethering and regulate Ca2+ signaling. In the mitochondrial fission process, DRP1 phosphorylated by protein kinase A (PKA) at serine 637...
As ER-mitochondrial tethering at MAMs could impact anti-cancer chemotherapeutic actions [20, 21, 40], we first investigated the correlation between MAM formation and CP-resistance of OC cells. Confocal imaging and PLA assays showed that the MAM number was remarkably higher in CP-resistant OC cel...
the mitochondrion at a distance that allows the formation of MERC tethers; however, the structural composition of its domains does not warrant to consider it a bona fide MERC tether. In this respect, the IP3R-grp75-VDAC complex does not have a tethering role24,71but, rather, a MERC ...
An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen. Communication between organelles is an important feature of all eukaryotic cells. To uncover components involved in mitochondria/endoplasmic reticulum (ER)... Kornmann,Benoît,Currie,... - 《Science》 被引量: 1142发表: 200...
CHMP7 undergoes dynamic assembly at three-way ER junctions and ER-mitochondrial MCSs through hydrophobic interactions among α helix-1 and α helix-2 of the C-terminal CHMP-like domain, which was required for tethering different organelles in vivo. Furthermore, CHMP7 mediates the formation of ...
The ER and mitochondria are often tightly associated at specific subdomains via tethering mediated by mitochondria-associated ER membrane (MAM) proteins. These contacts enable Ca2+transfer with high efficiency from the ER to mitochondria, which is necessary for mitochondrial metabolism.16However, dramatica...