Hirabayashi Y, Kwon S-K, Paek H, Pernice WM, Paul MA, Lee J, Erfani P, Raczkowski A, Petrey DS, Pon LA, Polleux F (2017) ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons. Science 358:623-630.
mitochondria是细胞内重要的细胞器之一,负责细胞内的能量代谢和调节,而内质网(ER)则是参与蛋白质合成和折叠的重要细胞器。mitochrondria-ER contacts蛋白则是位于线粒体和内质网之间的特殊蛋白质结构。 最近的研究发现,mitochrondria-ER contacts蛋白在维持线粒体的结构与功能中起着重要作用。它们通过连接线粒体和内质网...
Doghman-Bouguerra, M. and Lalli, E. (2016). ER-mitochondria contacts find their FATE. Cell Cycle 15, 3159-3160.Doghman-Bouguerra M, Lalli E. ER-mitochondria contacts find their FATE. Cell Cycle 2016; 15, 3159-3160; PMID:27579833; http://dx. doi.org/10.1080/15384101.2016.1220720...
Here we provide evidence, using live-cell super-resolution imaging, that nucleoids can be actively transported via KIF5B-driven mitochondrial dynamic tubulation (MDT) activities that predominantly occur at the ER-mitochondria contact sites (EMCS). We further demonstrate that a mitochondrial inner ...
Cyclooxygenase-2 modulates ER-mitochondria crosstalk to mediate superparamagnetic iron oxide nanoparticles induced hepatotoxicity: an in vitro and in vivo studyCyclooxygenase-2 modulates ER-mitochondria crosstalk to mediate superparamagnetic iron oxide nanoparticles induced hepatotoxicity: an in vitro and in vivo...
The endoplasmic reticulum (ER) is composed of the nuclear envelope, perinuclear sheets and a peripheral tubular network. The peripheral ER and mitochondria form tight contacts at specific subdomains, which coordinate the functions of the two organelles a
ER-mitochondria communication. How privileged? 来自 国家科技图书文献中心 喜欢 0 阅读量: 82 作者: C Franzini-Armstrong 摘要: Mitochondria have a low affinity for Ca2+, but they take up these ions during normal cell activity because they are in close proximity to the sites of calcium entry ...
Mitochondria-ER contact sites (MERCS) are known to underpin many important cellular homoeostatic functions, including mitochondrial quality control, lipid metabolism, calcium homoeostasis, the unfolded protein response and ER stress. These functions are
Accordingly, inhibition of Drp1 activity by Mdivi-1 treatment restored ER-mitochondria contacts, mitochondria dysfunction and Ca 2+ homeostasis. In sum , our results give new insight on how defects on mitochondria dynamics may contribute to striatal vulnerability in HD and highlights MAMs dysfunction ...
Mitochondria form close physical contacts with a specialized domain of the endoplasmic reticulum (ER), known as the mitochondria-associated membrane (MAM). This association constitutes a key signaling hub to regulate several fundamental cellular processes. Alterations in ER–mitochondria signaling have ...