The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into a...
[translate] aepithelial-to-mesenchymal transition (EMT), that confers on cancer cells traits associated with high-grade malignancy 上皮对mesenchymal转折(EMT),那在癌细胞特征商谈与高等级敌意相关[translate]
The epithelial to mesenchymal transition (EMT) is a key cellular process underlying cancer progression, with multiple intermediate states whose molecular hallmarks remain poorly characterised. To fill this gap, we present a method to robustly evaluate EMT transformation in individual tumours based on tran...
The epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cells lose epithelial characteristics, such as expression of E-cadherin, detach from neighboring epithelial cells, and become more migratory and invasive, all of which are characteristics of mesenchymal cells. In addition, ...
(EMTs), the acquisition of mesenchymal features from epithelial cells, occur during some biological processes and are classified into three types: the first type occurs during embryonic development, the second type is associated with adult tissue regeneration, and the third type occurs in cancer ...
Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer. Clin. Cancer Res. 13, 4769–4776 (2007) Article CAS Google Scholar Arumugam, T. et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer ...
Epithelial to Mesenchymal Transition (EMT), a process involved in organogenesis and wound healing is now at the center stage of cancer metastasis. While most of the current research is focused on defects arising in the nuclear genome, the contribution of defects in mitochondria has remained under ...
Epithelial–mesenchymal transition (EMT) is crucial in embryogenesis and can be exploited by cancer cells to gain metastatic abilities. A hallmark of EMT is E-cadherin loss. In 2000, Snail was reported as the first E-cadherin repressor identified in the context of EMT, advancing our understanding...
Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer Abstract The epithelial to mesenchymal transition (EMT) is an important step for the developmental process. Recent evidences support that EMT allows the tumor cells to acquire invasive properties and to develop ...
Epithelial-to-mesenchymal transitionOvarian cancerMembrane receptorsTreatment of epithelial ovarian cancer continues to advance, and molecularly targeted therapies that have been successful in treating other types of malignant disease have had varying levels of success in the treatment of patients with ...