Several investigations have shown that pregnancy and lactation are able to induce elongation of long bone by altering epiphyseal cartilage function in a prolactin-dependent manner. Since the transcription factor Sox9 is of utmost importance for chondrocyte proliferation and differentiation and since ...
The epiphyseal line, also known as the growth plate, is a line of hyanline cartilage that slowly shrinks and gets smaller as the long bones grow and... Learn more about this topic: Bone Growth, Development & Disorders from Chapter 13/ Lesson 11 ...
Partial loss of IFT80 function leads Jeune asphyxiating thoracic dystrophy (JATD) or short-rib polydactyly (SRP) syndrome type III, displaying narrow thoracic cavity and multiple cartilage anomalies. However, it is unknown how IFT80 regulates cartilage formation. To define the role and mechanism of...
Mutations in collagen IX, cartilage oligomeric matrix protein (COMP), and matrilin 3 have been reported to underlie this group of conditions (82). Patients have often been noted to have mild muscle weakness and a waddling gait, even if the hips are not significantly affected by the dyspla...
Bones elongate and children grow tall through the activities of a millimeter thin layer of cells wedged between the epiphyseal head and the diaphyseal shaft of the long bones. The form, function, and regulation of the activities of cells in this thin, tr
The histopathological examination of the removed enlargement showed normal cartilage and bone structure. Two months after operation the patient had no complaints and the knee function was normal. A t 1 2 years of age the patient had no problems with his knee joint, and the X-rays were ...
(16) recently demonstrated that the cartilage-specific gain of function of β-catenin by using a Col2-Cre system promotes cartilage canal formation and enhances Mmp9, -13, and -14 expression, resulting in an early occurrence of the SOC, and that cartilage-specific loss of function of β-cat...
Learn more about this topic: Epiphysis | Definition, Types & Function from Chapter 17 / Lesson 21 58K What is epiphysis? Learn the definition, types, and functions of the epiphysis. Also, explore and differentiate between the distal and proximal epiphysis. Related to this Question...
Cartilage Tissue Engineering; the search for chondrogenic progenitor cells and associated signalling pathways The socioeconomic cost of articular cartilage related diseases in the Western world is very high. The suffering of the individual patient is even more prob... M Thornemo - Springer New York ...
Dysplasia epiphysealis hemimelica is a rare skeletal developmental disorder characterized by asymmetric overgrowth of cartilage in the epiphyses. Due to the unusual and variable clinical picture, there is no standardized treatment and evolution is variable. We report the case of an 8 year-old boy, ...