The histone variant H3.3 plays key roles in regulating chromatin states and transcription. However, the role of endogenous H3.3 in mammalian cells and during development has been less thoroughly investigated. To address this gap, we report the production
Regardless of the exact definition, the epigenetic processes that stably alter gene expression patterns (and/or transmit the alterations at cell division) are thought to include: (1) cytosine methylation; (2) post- translational modification of histone proteins and remo- delling of chromatin; and ...
Therefore, we conducted chromatin immunoprecipitation (ChIP)-qPCR, and the results showed that there were significant increases in H3K27me3 signals at the PRKCA and MCL1 loci when cells were treated with GSK-J4; these results were reversed when cells were treated with EPZ-6438 (Fig. 7a). ...
Epigenetics & Chromatin BioMed Central Research Open Access Tissue-specific variation in DNA methylation levels along human chromosome 1 Cecilia De Bustos†1,8, Edward Ramos†2,3,9, Janet M Young†2, Robert K Tran4,10, Uwe Menzel1, Cordelia F Langford5, Evan E Eichler3,6, Li Hsu7,...
Alongside this, HDAC8 has been identified as a key player in MASH-induced HCC, driving oncogenic pathways and chromatin modifications. Knocking down HDAC8 reverses IR and decreases tumorigenicity associated with MASLD [47]. Other research has demonstrated that the deacetylation of histone H4 lysine ...
Cellular metabolism (or energetics) and epigenetics are tightly coupled cellular processes. It is arguable that of all the described cancer hallmarks, dysregulated cellular energetics and epigenetics are the most tightly coregulated. Cellular metabolic s