Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives. Trends Parasitol. 2012; 28 :202–213. [ PMC free article ] [ PubMed ]Croken MM, Nardelli SC, Kim K (2012) Chromatin modifi
“In this study, we successfully analysed the transcription, epigenome and 3D genome organization in mammalian cells that, for the first time, lacked all three major repressive chromatin modifications: H3K9 methylation, H3K27me3, and uH2A. Our findings revealed that, in the absence of H3K9 methy...
“In this study, we successfully analysed the transcription, epigenome and 3D genome organization in mammalian cells that, for the first time, lacked all three major repressive chromatin modifications: H3K9 methylation, H3K27me3, and uH2A. Our findings revealed that, in the absence of H3K9 methy...
Histone modifications: insights into their influence on gene expression. Cell 175, 6–9 (2018). CAS PubMed Google Scholar Li, X., Egervari, G., Wang, Y., Berger, S. L. & Lu, Z. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nat. Rev. Mol. Cell...
Chromatin remodelling or epigenetics refers to genome modifications without a change in nucleotide sequence and affects the degree and pattern of gene expression via processes such as histone modification and DNA methylation. From:Ageing Research Reviews,2023 ...
A. Epigenetics in cancer. Carcinogenesis 31, 27–36 (2010). CAS PubMed Google Scholar Jasencakova, Z. & Groth, A. Replication stress, a source of epigenetic aberrations in cancer? Bioessays 32, 847–855 (2010). CAS PubMed Google Scholar Kouzarides, T. Chromatin modifications and ...
Recent reports have highlighted how SARS-CoV-2 infection and the resulting COVID-19 can turn epigenetics against us; however, new research now reveals that the epigenetic machinery can also help us fight back against viral attacks – in the guise of specific RNA modifications. A team of epigene...
Epigenetic phenomena have been associated with the regulation of active and silent chromatin states achieved by modifications of chromatin structure through DNA methylation, and histone post-translational modifications. The latter is accomplished, in part, through the action of PcG (Polycomb group) protein...
as supported by genome-wide localization and analyzed in several dynamic systems, are an excellent example of transcriptional control. Posttranslational modifications such as acetylation and ubiquitination of H2A.Z, as well as its specific binding partners, are in our view central players in the contr...
Other studies have explored patterns of cancer DNAm in relation to gene expression patterns in the corresponding normal tissue, but were not highly quantitative, did not consider histone modifications and only used DNAm data from the older Illumina 27k technology [17, 18]. Further, motivated by...