Epimorphin-derived peptide antagonists remedy epidermal parakeratosis triggered by unsaturated fatty aciddoi:10.1016/j.jdermsci.2010.07.004EpidermisHyperplasiaEpimorphinAntagonistSyntaxinOleicacidBackground Unsaturated fatty acid from accumulated sebum disrupts calcium influx in keratinocytes and triggers epidermal ...
Both psoriasis plaques and imiquimod-induced psoriasiform dermatitis are characterized by increased inflammatory cell infiltrate, epidermal hyperplasia, and parakeratosis. A successful treatment for psoriasis is therefore directly associated with reduced inflammation and reduction of psoriasiform acanthosis, which...
which are characterized by skin hyperkeratosis and scaling. Some MeDOC types are associated with defects of the epidermal lipid metabolism, resulting in perturbed barrier permeability and subsequent epidermal hyperplasia, hyperkeratosis and inflammation. An ...
Sign up with one click: Facebook Twitter Google Share on Facebook intraepidermal Medical [¦in·trə‚ep·ə′dər·məl] (anatomy) Within the epidermis. McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc. ...
6. Epidermal keratinocytes play critical roles in the pathogenesis of psoriasis. Various inflammatory cytokines, chemokines and growth factors can be strongly induced in the keratinocytes of psoriatic lesions, causing inflammation, epithelial hyperplasia and immune cell mobilization, ultimately resulting in ...
Histologic analysis reveals epidermal psoriasiform hyperplasia with characteristic alternating orthokerato-sis and parakeratosis. Lesions may be difficult to distinguish from linear psoriasis because of their clinical and histopathologic similarities.Unlike psoriasis, ILVEN is typically refractory to treatment, ...
Histopathologic examination of an excisional biopsy specimen showed epidermal hyperplasia and focal parakeratosis. In the upper dermis there were focal collections of deep blue staining calcified material surrounded by some lymphocytes and histiocytes (Fig. 2). The surrounding dermis contained numerous ...
In the active phase of psoriasis presence of hypertension aggravates the degree of local damage of the epidermis, strengthening the development of hyperkeratosis, parakeratosis, papillomatous hyperplasia, extracellular and cytoplasmic edema of epidermocytes, separation and detachment of the epidermis due ...
The typical histopathologic features are alternating parakeratosis and orthokeratosis with an absent granular layer underneath parakeratosis, in contrast to a thickened granular layer below the foci of orthokeratosis in psoriasiform epidermal hyperplasia. Herein, we present a 49-year-old woman with ...
1,4 However, it regularly features the presence of localized epidermal papillomatosis, with hyperkeratosis, hypergranulosis, and fusion of rete pegs. With time, varying degrees of adnexal hyperplasia are superimposed on this description, such that excess numbers of sebaceous glands and apocrine ...