(1993) Induction of epidermal hyperplasia, hyperkeratosis and papillomas in transgenic mice by a targeted v-Ha-ras oncogene. Mol. Carcinogen., 7, 99±110.Greenhalgh DA, Rothngel JA, Quintanilla MI, et al. Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by...
Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa (HS). The presence of an occasional thickening of lesional skin in some folliculitis decalvans (FD) patients and histological similarities ...
et al . (1993) Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v- fos oncogene suggest a role for fos in ... DA Greenhalgh,JA Rothnagel,XJ Wang,... - 《Oncogene》 被引量: 101发表: 1993年 Skin hyperkeratosis and papilloma formation in transgenic ...
More aggressive disruption of the epidermis by repetitive razor abrasion resulted in an even greater transepidermal waterloss in LC-intact epidermis that showed histological evidence of epidermal hyperplasia and hyperkeratosis (Figure 6d and e) and augmented expression of IL-22, IL-1β, and IL-23 ...
Hyperplasia of the epidermis with regular elongation of rete ridges, hyperkeratosis, increased proliferative basal layer epidermal keratinocytes, dilated capillaries, microabscesses and massive dermal cellular infiltrates were histologically evident in the IMQ-treated mouse skin (Supplementary Fig. 1c). ...
, 2005). Transgenic overexpression of TGF-α leads to tissue hyperplasia and hyperkeratosis, with spontaneous squamous papillomas occurring at sites of wounding in adult animals in the absence of skin inflammation (Dominey et al., 1993). By contrast, transgenic expression of amphiregulin in either...
invol- ving inflammation, proliferation and remodeling18 takes place by which basal keratinocytes together with hair follicle stem cells are able to replace the epidermal cell population.19,20 Deregulation of these processes can lead to severe skin diseases such as hyperkeratosis, hyperplasia or ...
Transverse sections with hematoxylin staining in- dicated that the forcible expression of syntaxin-4 resulted in hyperplasia in the denucleated epidermal layer, which was prone to being antagonized by ST4n1 (Figure 5A). Consistent with this, the restricted expression pattern of ST4n1 Remedies ...
1,4 However, it regularly features the presence of localized epidermal papillomatosis, with hyperkeratosis, hypergranulosis, and fusion of rete pegs. With time, varying degrees of adnexal hyperplasia are superimposed on this description, such that excess numbers of sebaceous glands and apocrine ...
Epidermal differentiation seems to be affected in nkt skin, with overexpression of involucrin and profilaggrin/filaggrin along with focal areas of keratin 6 expression in the interfollicular epidermis. Severe epidermal hyperplasia, acanthosis, orthokeratosis, and hyperkeratosis were only observed in mice ...