This report describes a 42-year-old woman who presented with a pruritic skin condition on her arms and legs of 13 years' duration. Skin biopsy results showed epidermal hyperplasia with hyperkeratosis, hyperpigmentation of the basal layer with mild acanthosis, and evidence of amyloid deposi...
Follicular hyperkeratosis along with hyperplasia of the follicular and interfollicular epithelia are major histopathological characteristics of hidradenitis suppurativa (HS). The presence of an occasional thickening of lesional skin in some folliculitis decalvans (FD) patients and histological similarities ...
More aggressive disruption of the epidermis by repetitive razor abrasion resulted in an even greater transepidermal waterloss in LC-intact epidermis that showed histological evidence of epidermal hyperplasia and hyperkeratosis (Figure 6d and e) and augmented expression of IL-22, IL-1β, and IL-23 ...
Histopathology of NS reveals variable epidermal hyperplasia with hyperkeratosis, acanthosis, or papillomatosis. Sebaceous glands are frequently hyperplastic and numerous but can be hypoplastic or even absent. Hair follicle abnormalities are present in essentially all lesions, and typically have an embryonic...
Targeted overexpression of transforming growth factor alpha in the epidermis of transgenic mice elicits hyperplasia, hyperkeratosis, and spontaneous, squam... To assess the effects of transforming growth factor alpha (TGF-alpha) on mammalian skin in vivo, we have targeted its expression to the epide...
Hyperplasia of the epidermis with regular elongation of rete ridges, hyperkeratosis, increased proliferative basal layer epidermal keratinocytes, dilated capillaries, microabscesses and massive dermal cellular infiltrates were histologically evident in the IMQ-treated mouse skin (Supplementary Fig. 1c). ...
1,4 However, it regularly features the presence of localized epidermal papillomatosis, with hyperkeratosis, hypergranulosis, and fusion of rete pegs. With time, varying degrees of adnexal hyperplasia are superimposed on this description, such that excess numbers of sebaceous glands and apocrine ...
Psoriasis is a skin disorder of chronic keratinization characterized by epidermal hyperplasia, hyperkeratosis, and inflammation. However, little is known a... CS Shen,T Tsuda,S Fushiki,... - 《Journal of Dermatology》 被引量: 42发表: 2005年 ...
, 2005). Transgenic overexpression of TGF-α leads to tissue hyperplasia and hyperkeratosis, with spontaneous squamous papillomas occurring at sites of wounding in adult animals in the absence of skin inflammation (Dominey et al., 1993). By contrast, transgenic expression of amphiregulin in either...
invol- ving inflammation, proliferation and remodeling18 takes place by which basal keratinocytes together with hair follicle stem cells are able to replace the epidermal cell population.19,20 Deregulation of these processes can lead to severe skin diseases such as hyperkeratosis, hyperplasia or ...