Epithelial cell adhesion molecule (EpCAM) is an important biomarker in tumors. In hepatocellular carcinoma (HCC), EpCAM + cells exhibit high invasiveness, tumorigenic ability, therapeutic resistance, and self-renewal ability, often identified as liver cancer stem cells (CSCs). Detecting EpCAM...
Abstract 6373: Spheroid culture of ER+ breast cancer patient-derived tumor cells enriches cancer stem-likecells with EpCAM-/CD49f+and high ALDH activity and poor prognostic gene signaturesdoi:10.1158/1538-7445.AM2022-6373Background: Cancer stem-like cells (CSCs) represent a critical subset of ...
The Epithelial Cell Adhesion Molecule (EpCAM) has been shown to be strongly expressed in human breast cancer and cancer stem cells and its overexpression has been supposed to support tumor progression and metastasis. However, effects of EpCAM overexpression on normal breast epithelial cells have neve...
目的:探讨早期低危子宫内膜腺癌癌组织中上皮细胞黏附分子EpCAM,CD44v6的表达与早期低危子宫内膜腺癌远处转移及预后的关系,并指导临床.方法:病理检查确诊的早期低危子宫内膜腺癌患者共118例,根据随访中是否发生远处转移分为两组:A组72例为无远处转移者,B组46例为有远处转移者.取A,B两组手术中切除的癌组织,采用免...
EpCAM is frequently expressed at high levels in various epithelial cancers (carcinomas)2and in undifferentiated human embryonic stem cells3,4. Elevated EpCAM levels in carcinomas are exploited by several anti-tumor approaches, which deploy EpCAM for drug targeting (reviewed in ref.5) and a trif...
4). Notably, the majority of mAbs that recognize EpCAM on cancer cells bind specifically to this 6 kDa part, underlining its high immunogenicity [48], [57]. A number of proteases, including serine proteases trypsin and chymotrypsin, have been shown to be able to conduct this N-terminal ...
Expression of CD44 protein was confirmed by flow cytometry (Figure 1D). Monoclonal anti-EpCAM antibody G8.8-induced proliferation After 48 h of treatment, monoclonal rat anti-mouse EpCAM antibody G8.8 dose-dependently increased the number of metabolically active cells. A significant increase in ...
The effector molecule is preferably a cancer therapeutic agent. The cancer therapeutic agent is preferably a toxin that is either cytotoxic, cytostatic or otherwise prevents or reduces the ability of the cancer cells to divide and/or metastasize. Accordingly, one aspect of the invention is an immun...
On the other hand, the up-modulation of PLC-尾2 in the whole MDA-MB-231 cell population reduced the number of cells with a CD44+/CD133+/EpCAM+stem-like phenotype. Since selective targeting of the cells with the highest aggressive potential may have a great clinical importance for TNBC, ...
Most studies on CTCs have focused on isolating cells that express EpCAM. In this study, we emphasize the presence of EpCAM-negative and EpCAMlow CTCs, in addition to EpCAMhigh CTCs, in early BC. We evaluated stem cell markers (CD44/CD24 and CD133) and EM