tumor cells, epithelial cell adhesion molecule, hepatocellular carcinoma *S.R. and H.W. contributed equally to this work Conflicts of interest: Nothing to report Grant sponsor: Deutsche Forschungsgemeinschaft (DFG); Grant number: SFB 841, Project C5; Grant sponsor: European ...
From 87 patient samples we could isolate EpCAM-positive cells. We performed single cell RNA-sequencing on 64 EpCAM-positive cells from 54 patients of which 84% were classified as cancer cells and 16% of bone marrow origin. Applying the selected gene signature, 76% of isolated cells were ...
EpCAM-positive CD90-negative epithelial HCC cells (Huh1, Huh7, and HCC cells) were converted into metastasis-prone CD90-positive HCC cells by co-culture with fibroblasts (Lx-2 and Tig3-20). We identified the transcription factor JUNB as responsible for this altered phenotype. We found that...
Cells of interest remain in the tube while unwanted cells are poured off. The EpCAM+ fraction contains luminal cells, luminal-restricted, and bipotential progenitor cells. This product replaces the EasySep™ Human EpCAM Positive Selection Kit (Catalog...
摘要: Hepatocellular carcinoma (HCC) originates from regenerating liver cells with genetic alterations in chronically inflamed liver. Ductal cells and hepatocytes proliferate for liver r... 查看全部>>DOI: 10.1158/0008-5472.can-17-1800 年份: 2017 ...
circulating biomarkersEpCAM (CD326)flow cytometrymethodologymicroparticlesmicrovesiclesExtracellular vesicles (EV) have attracted attentidoi:10.1111/gtc.12645Takao MasashiNagai YutakaIto MasamiOhba TetsuhikoGenes to Cells
Furthermore, EpCAM-positive cell lines (Huh1, Huh7, HepG2, and Hep3B) had lowerPCDH18expression than EpCAM-negative cell lines (PLC/PRL/5, HLE, HLF, and SK-Hep-1), andPCDH18knockdown in HCC2 cells slightly enhanced cell proliferation. Our data suggest thatPCDH18is functionally ...
Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma. Int J Cancer. 2013;133(9):2165–71.Schulze K, Gasch C, Staufer K, Nashan B, Lohse AW, Pantel K et al (2013) Presence of EpCAM-...
An Electroactive Biotin‐Doped Polypyrrole Substrate That Immobilizes and Releases EpCAM‐Positive Cancer Cells. Angew Chem. 2014; 126: 4685-90.Jeon, S. H.; Moon, J. M.; Lee, E. S.; Kim, Y. H.; Cho, Y. An Electroactive Biotin-Doped Polypyrrole Substrate That Immobilizes and Releases...
Results : EpCAM-positive cells were detected in the lymph nodes from 9 of 38 patients (23.7%). Originally 1 of 8 cases (12.5%) was juged as pT1, pN0 and 8 of 30 cases (26.7%) were juged as pT2, pN0 by conventional histopathology. Patients without any EpCAM-positive lymph node...