32. Targeting Ly6Chimonocyte recruitment to attenuate inflammation enhances myocardial repair33,34, whereas reparative Ly6CloCCR2–CXCR1hi(CD14dimCD16+in humans) monocytes produce VEGF and TGF-β that promote angiogenesis, extracellular matrix protein synthesis, and myocardial healing23,35. We monitored ...
Eosinophils are a minor subset of the granulocyte lineage distinguished by their unique morphology, phenotype, cytoplasmic contents, and function. Evolutionarily, these are ancient cells whose existence has been conserved within vertebrates for millions of years, suggesting that their contribution to innate...
are also involved in several homeostatic processes, including metabolism, tissue remodeling and development, neuronal regulation, epithelial and microbiome regulation, and immunoregulation, indicating that these cells may play a crucial role in metabolic regulation and organ function in healthy humans. Conseq...
Single-cell transcriptomic profiling and functional assays are used to identify subpopulations of eosinophils that are present in the mouse gastrointestinal tract and provide insight into the role of these cells in inflammatory bowel diseases in humans. ...
Taken together, our study identifies a novel role for Eos in the regulation of humoral immunity via their impact on B cell homeostasis and proliferation upon activation. 展开 关键词: Lymphoid Tissue B-Lymphocytes Eosinophils T-Lymphocytes Animals Mice, Transgenic Humans Mice Eosinophilia Lymphocytosis ...
In humans, the number and the activity of eosinophils correlates with bone mass in healthy participants and rheumatoid arthritis patients. Taken together, experimental and human data indicate a regulatory function of eosinophils on bone.Similar content being viewed by others Estrogens decrease osteoclast ...
Neurohormonal and inflammatory hyper-responsiveness to acute mental stress in depression Depression is associated with dysregulated hypothalamic–pituitary–adrenal (HPA) axis function, overactivity of the sympathoadrenal system, and increased ... AA Weinstein,PA Deuster,JL Francis,... - 《Biological ...
In humans, the number and the activity of eosinophils correlates with bone mass in healthy participants and rheumatoid arthritis patients. Taken together, experimental and human data indicate a regulatory function of eosinophils on bone.Similar content being viewed by others Ncf1 affects osteoclast ...
The effector function is thought to be related to the release of highly cytotoxic, granule-associated cationic proteins following stimulation of eosinophils. In spite of strong arguments in favor of either end of this spectrum, the evidence remains circumstantial; the precise role of this cell in ...
She mentions that the findings would support a significant prosurvival and antiviral role for eosinophils and would contend against the concept that degranulation of eosinophil might be granulocyte lineage's vestigal function. She says that caution would be recommended in the use of therapeutic ...