Despite a number of studies exploring the function of PTPN22 in T cells, the exact impact of the PTPN22 risk allele on T-cell function in humans is still unclear. In this study, using RNA sequencing, we show that, upon TCR-activation, nave human CD4+ T cells homozygous for the PTPN22 ...
Anti-Dog CD4 -PE-Cyanine7/小鼠抗狗CD4,PE-Cyanine7 产品类型:流式抗体 规格:25 Tests,100 Tests AD0404125 ,AD0404110 我要询价 添加 RevertAid First Strand cDNA Synthesis Kit/反转录第一链cDNA合成试剂盒 cDNA合成试剂盒; 42°C最佳活性温度; 完全组份试剂盒; 高效合成长达13kb cDNA ...
本文使用地塞米松处理健康人外周血单个核细胞(PBMCs)72 h后,探究其对CD4+T细胞及其亚群的频数、增殖、凋亡比例;功能性细胞因子及关键转录因子表达的影响.结果显示,地塞米松组CD4+T、2型辅助性T细胞(Th2)、Th17细胞比例增加(P<0.01,P<0.05,P<0.01),Th1细胞比例降低(P<0.01).Th1细胞上γ-干扰素(IFN-...
Eomes对CD4+ T细胞的调节作用尚在研究中,但Eshima等已发现仅单独引入Eomes基因就可通过穿孔素和FasL途径使已分化完全的 Th细胞功能向CTL细胞功能转变 [7]。1.2T-bet和Eomes对CD8+ T细胞的调控作用 CD8+ T细胞在机体抗感染和抗肿瘤免疫应答中有不可替代的作用。 T-bet和Eomes共同调控 CTL靶基因的转录 [8]。T-...
CD4SP, and CD8SP thymocytes (Fig.5a). Apart from higher CD8SP/CD4SP and DN/DP ratios, we did not observe major perturbations of T cell development in theseEomesTgmice. We then assessed the phenotype and activation status of CD3+CD8SP thymocytes from these mice under steady-state conditions...
A medical hypothesis is formulated here: the existence of a CD137 (4.1BB)-Eomesodermin (Eomes) activated pathway downstream of TCR-specific activation in a subpopulation of CD4 + FoxP3 + T cells may explain this effector function. Evidence suggest that this axis may exist either in ...
EOMES and T-BET balance each other during NK cell maturation and activation To explore the roles of T-BET and EOMES in NK cells, we first measured the expression of both TFs during maturation. To unambiguously analyze NK cells and exclude ILC1s we defined NK cells as CD49B + CD49A...
30 Both CD8 and CD4 T cell counts were increased in the spleen and liver of Pdcd1−/− mice compared with WT mice (Figure 1A). However, by comparing the CD8-to-CD4 ratios in both strains and organs, we observed a preferential expansion of CD8+ T cells in the liver of Pdcd1−...
T-bet和Eomes是调控CD4+Th1cells和CD8+CTLs等I型效应T细胞分化和功能的重要转录因子。已有研究表明,肿瘤患者的生存期与转录因子T-bet和Eomes表达密切相关,肿瘤浸润淋巴细胞(TILs)中T-bet和Eomes表达水平高的癌症患者生存期显著延长。最近的研究结果显示T-bet和Eomes在由CD8+T细胞介导的抗肿瘤免疫应答中发挥重要调节...
转录因子Tbet、Eomes和IL33对CD8记忆和效应T细胞抗肿瘤的作用机制 热度: 转录因子Stat5对Foxp3CD4调节性T细胞发育的重要作用 热度: 转录因子RFX1调控狼疮T细胞CD11a和CD70基因表达的表观遗传机制研究--优秀毕业论文 热度: ! QQ!=! 细胞与分子免疫学杂志(ChinJCellMolhnnmno1)2010,26(1) ...