ultrarapid metabolismgene duplicationpoor metabolisersPolymorphism in drug-metabolising enzymes is of great importance for interindividual differences in drug therapy. Variant genes causing increased, decreased or abolished drug metabolism influences the drug response and risk for adverse drug reactions. The ...
The potential for large-scale synthesis of drug metabolites using this methodology has been explored.doi:10.1096/fasebj.2.7.3127263Dulik, D MFenselau, CFASEBThe FASEB JournalD.M. Dulik, C. Fenselau, Use of immobilized enzymes in drug metabolism studies, FASEB J. 2 (1988) 2235-2240....
Cytochrome \{P450\} enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation 来自 Elsevier 喜欢 0 阅读量: 99 作者:Ulrich,M.,Zanger,and,Matthias,Schwab 摘要: Cytochromes \\{P450\\} (CYP) are a major source of variability in drug ...
网络药物代谢酶 网络释义 1. 药物代谢酶 2.药物代谢酶药物在体内的转化是在酶的催化下进行,这些催化药物转化的酶,统称为药物代谢酶(drug metabolism enzyme… book.jd.com|基于13个网页
5.07 – Principles of Drug Metabolism 3: Enzymes and Tissuesinstrument response timemeasurement systemThis chapter provides an overview of the main classes of drug-metabolizing enzymes – oxidases, reductases, hydrolases, and transferases – in terms of their multiplicity, nomenclature, three-...
1.Drug metabolism enzymes(DME) play a significant role in drug detoxification and activation,which exert important effect on drug efficacy and sensitivity to toxicity.药物代谢酶(DME)在药物代谢解毒和药物代谢活化中起着重要的作用,对组织器官的药物效应和毒性的易感性产生重要影响。 2.Objective:The effects...
MOLECULAR INTERACTIONS BETWEEN MYCOTOXINS AND LIVER ENZYMES INVOLVED IN DRUG METABOLISM IN RODENTS AND FARM ANIMALS 来自 ResearchGate 喜欢 0 阅读量: 34 作者:P Galtier,GM Meissonnier,J Laffitte,IP Oswald,N Loiseau 摘要: Mycotoxins are well known for underging liver biotransformation in humans and ...
Overall, the FDA "encourages the identification of differences in drug metabolism between animals used in nonclinical safety assessments and humans as earl... S Services,Why,When,... 被引量: 0发表: 2009年 Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites Human...
The manuscript also emphasizes the role of environmental factors (in addition to genetic polymorphisms) in explaining person-to-person and day-to-day differences in rates and pathways of drug metabolism that occur in the human population.关键词: environmental regulation of xenobiotic metabolism ...
During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only... DSND Wildt,GL Kearns,JS Leeder,... - 《Clinical Pharmacokinetics》 被引量: 392发表: 1999年 Glucuronidation in Humans: Pharmacogenetic and ...