The chapter describes the metabolic reactions known to occur in red cells, and the systems of transport by which various substances enter and leave the cell and which are thought to be under enzymic control. Both processes are closely integrated, but reflect two entirely different experimental ...
Aspects of metabolic control theory and experiments from metabolic biochemistry are reviewed in order to deduce the circumstances in which experimental studies involving metabolomics have the greatest chance of success. It is concluded that metabolic changes effected mainly through a single enzyme are those...
The integration of a new orthogonal redox cofactor opens opportunities for controlling reaction equilibria. Because it does not interfere with cellular redox homeostasis, this approach enables the precise tuning of metabolic pathways and the optimization of microbial bioproduction, independently of canonical ...
Most of the pathways in MetaCyc occur in microorganisms and plants, although animal pathways are also represented. MetaCyc contains metabolic pathways, enzymatic reactions, enzymes, chemical compounds, genes and review-level comments. Enzyme information includes substrate specificity, kinetic properties, ...
Inactivation of metabolic enzymes caused disruption of cancer cells' metabolism and is likely to be one of the major reasons for antiproliferative activity of ZnTM-3-PyP. 展开 关键词: Photodynamic therapy Zn meta N-methylpyridylporphyrin Enzyme inactivation NADPH production Cancer cell glycolysis MTT...
Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead Burkholderia pseudomallei is a species of bacteria that poses a global health threat and, more generally, bacteria of the Burkholderia pseudomallei group cause severe diseases that are recalcitrant to treatment with anti...
While the percentage of orphan enzyme activities has decreased from 38% to 22% in ten years, there are still more than 1,000 orphans among the 5,000 entries of the Enzyme Commission (EC) classification. Taking into account all the reactions present in metabolic databases, this proportion ...
food chemistry Enzymes
(see aboveNucleic acids and proteins); these in turn are built up from intermediates of central metabolic pathways (see above). The first step in the synthesis of pyrimidine nucleotides is that catalyzed by aspartate carbamoyltransferase. This step initiates a sequence of reactions that leads to ...
Chemistry, AnalyticIn the present work the metabolic response of to deletion of the global transcriptional regulator McbR, which controls, e.g. the express... Kromer,JO Bolten,CJ Heinzle,... - Chapman & Hall, 被引量: 66发表: 2008年 加载更多来源...