CELL linesCHROMOSOMAL rearrangementCELL separationCELL cultureHOMEOSTASISEnteric glial cells (EGCs), the major components of the enteric nervous system (ENS), are implicated in the maintenance of gut homeostasis, thereby leading to severe pathological conditions when impaired. However, ...
Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to... M Saarma,H Sariola - 《Microscopy Research & Technique》 被引量: 384发表: 1999年 Effects of dexamethasone exposure on rat metanephric ...
coordinated programs of self-renewal and differentiation, generate integrated networks of diverse neuronal and glial cell types throughout the gut6,7. The critical roles of the ENS in survival and health are highlighted by developmental deficits, such as Hirschsprung’s disease (congenital megacolon),...
GLIAL cell line-derived neurotrophic factorCYCLIC-AMP-dependent protein kinaseENDOTHELINSGASTROINTESTINAL systemTRANSGENIC miceNEURAL circuitryEnteric neural crest-derived cells (ENCCs) migrate from the anterior foregut in a rostrocaudal direction to colonize the entire gastroin-t...
Comparable to the NMU-mediated signaling from enteric neurons to ILC2, EGCs can respond to microbial-associated molecular patterns in a Myd88-dependent manner by releasing the RET-ligand glial cell line-derived neurotrophic factor (GDNF), which stimulates neighboring ILC3s-expressing the RET receptor...
119,120,121 Interestingly, the activation of TLR2 and TLR4 on glial cells by commensal bacterial products can increase the release of glial cell line-derived neurotrophic factor (GDNF)-family ligands that bind to RET expressed on ILC3 (Fig. 2f), stimulating the secretion of IL-22 and ...
Aim The aim of this study was to establish a three-dimensional model of the innervated mucosal barrier using a co-culture of an enterocyte cell line and enteric glial and nerve cells. Such a model might form the basis for further studies of interactions between the single compartments of the...
Glial Cell Line-derived Neurotrophic Factor Induces Ret-mediated Lamellipodia Formation Ret is a receptor tyrosine kinase required during embryogenesis for the survival of enteric and sympathetic neuroblasts. Recently, glial cell line-derived neurotrophic factor (GDNF) has been identified as a ligand for...
α-7 nAchR Is Present on in Vitro Intestinal Epithelial Cells and Enteric Glial Cells First, we analyzed whether α-7 nAchR is present on cultured intestinal epithelial cells. Caco-2 cells, a human intestinal epithelial cell line were grown in confluent monolayers. Cells were harvested and immuno...
et al. Enteric glial cells are susceptible to Clostridium difficile toxin B. Cell. Mol. Life Sci., doi: 10.1007/s00018-016-2426-4 (2016). Farrow, M. A. et al. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc. Natl. ...