In addition to further rearrangements, RCS can lead to AGEs such as Nε-carboxyethyllysine (CEL), arginine pyrimidine, pentosidine, pyrralin, methylglyoxal, glyoxal lysine and Nε-carboxymethyllysine (CML). Due to the different AGE-precursors, AGEs are a very complex and heterogeneous group of ...
3.1 A structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids J. Struct. Biol., 207 (2019), pp. 270-278 View PDFView articleView in ScopusGoogle Scholar 41 S. Aibara, C. Dienemann, P. Cramer Structure...
In addition, a paired guanine (G) followed by a pyrimidine (Y) and a mismatched cytosine or adenine (M) (GYM motif) near the cleavage site promotes Dicer processing at a specific position [37]. Thus, several structural features of pre-miRNA regulate miRNA matura- tion pathway by modulating...
and cluster of differentiation 36 (CD36). The interaction of AGEs with these receptors can enhance their catabolism and clearance by modulating endocytosis and degradation45,46, suggesting a potentially adaptive defensive mechanism in the body to reduce the detrimental effects of increased glycation pro...
inhibitors of the RAGE signaling pathway130,131, neutralizing antibodies against RAGE57 or AA-AGE adduct199, and other AGE-degrading compound(s), such as pyridoxamine and ALT-711200, lipoic acid291, synthetic compounds OPB-9195292, and nitrothiadiazolo[3,2-α]pyrimidines293, have been reported ...
Uniform 2′-O-methoxy ethyl substituted oligonucleotides with a full phopshorothioate backbone and 5-methyl U and C as the pyrimidine heterocycle were prepared on solid support with standard phosphoramidite chemistry. All ASO sequences are included in the Supplemental Experimental Procedures. ASOs were...
AGEs are relatively insoluble, yellow-brown in color and a majority of them exhibit a fluorescence phenomenon. CML, pentosidine, argypyrimidine, pyrraline, imidazolone, 2-(2-furoyl)-4(5)-furanyl-1H-imidazole (FFI), glyoxal-lysine dimer (GOLD), methylglyoxal-lysine dimer (MOLD), 3-deoxy...
While epoxy-based composites are suitable for many applications, their brittle nature and susceptibility to degradation make them inadequate for many aerospace applications, especially those applications which require thermally stable, tough composites. Accordingly, research has recently focused on polyimide co...
6-trimethoxy benzene, 3-methyl uracil, dihydrouridine, naphthyl, aminophenyl, 5-alkylcytidines (e.g., 5-methylcytidine), 5-alkyluridines (e.g., ribothymidine), 5-halouridine (e.g., 5-bromouridine) or 6-azapyrimidines or 6-alkylpyrimidines (e.g. 6-methyluridine), or propyne ...
Compounds of the general structure XXXIV, can be obtained by acylation of commercially available 5,6-diaminopyrimidine-4(3H)-one (XXXV) with the appropriate carboxylic acid to introduce subsitutent R1 using a suitable activator such as HATU, HBTU, O-(benzotriazol-1-yl)-N,N,N′,N′-...