AGEs gradually accumulate during the aging process through normal metabolic and glycation activities. The aggregation of AGEs from endogenous and/or exogenous sources can negatively affect the functions of many cells in the entire body, resulting in diverse cellular responses and ultimately cellular damage...
AGEs are relatively insoluble, yellow-brown in color and a majority of them exhibit a fluorescence phenomenon. CML, pentosidine, argypyrimidine, pyrraline, imidazolone, 2-(2-furoyl)-4(5)-furanyl-1H-imidazole (FFI), glyoxal-lysine dimer (GOLD), methylglyoxal-lysine dimer (MOLD), 3-deoxy...
glyoxal-derived hydroimidazolones; G-DH: glyoxal-derived dihydroimidazolones; MG-H: methylogloxal-derived hydroimidazolones; MG-DH: methylglyoxal-derived dihydroimidazolones; THP: Nδ-(4-carboxy-4,6-dimethyl-5,6-dihydroxy-1,4,5,6-tetrahydropyrimidine-2-yl)-l-ornithine; CMA: Nx-carboxymethyl...
In more detail, they can add a second methylglyoxal molecule yielding either THP (5.5, Nδ-(4-carboxy-4,6-dimethyl-5,6-dihydroxy-1,4,5,6-tetrahydropyrimidine-2-yl)-L-ornithine) through an open intermediate [Citation133] and a final re-cyclization reaction or argpyrimidine, (5.6, Nδ-(...
The role of cAMP signaling was reported in several DNA repair mechanisms. α-Melanocyte-stimulating hormone stimulates the repair of UVR-induced cyclobutane pyrimidine dimers through stimulating nucleotide excision repair (NER)19. cAMP signaling was reported to stimulate NER by phosphorylation of ataxia ...
Results: ChIP-Seq revealed hnRNPK accumulation at 3′-ends of immediate early genes. HnRNPK knockdown altered degradation of RNA downstream of poly(A) at EGR1 by decreased binding of XRN2 exonuclease. Conclusion: HnRNPK facilitates XRN2 recruitment influencing co-transcriptional 3′-end mRNA proce...
An end structure with a terminal pyrimidine:pyrimidine mispair (C:T) was also included (TCGC30). Finally, parallel versions of these 30 overhang substrates with opposite overhang polarity (50) were generated. As expected, a fully complementary 30 overhang was rarely processed before ligation; 88%...
We observed three pathways, present in at least 30% of the participants, that were nominally (p < 0.05) associated with SAF: positive associations with the superpathway of L-aspartate and L-asparagine biosynthesis, pyrimidine deoxyribonucleosides salvage, and L-histidine degradation I. However, no...
The methylglyoxal-derived age tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with svcam-1. Diabetologia 2013, 56, 1845–1855. [Google Scholar] [CrossRef] [PubMed] Gaens, K.H.; Goossens, G.H.; Niessen...
hemoglobin glycation can result in modifications to its secondary structure and even the degradation of heme groups. Moreover, these structural alterations can impair the functional efficacy of hemoglobin and other proteins, leading to various complications in vivo, such as aging, cataracts, uremia, an...