fused pyrimidine derivatives2-Aminopyrimidine and 2-amino-4-methylpyrimidine react with allenic nitriles to give, initially, 2-imino-4-alkylpyrimido[1,2-a]pyrimidines (2) which rapidly add water and cleave to 3-(4-amino-6-alkyl-2-pyrimidylamino)aldehydes (6). 2-Amino-4,6-...
Significance of the caffeine-like effect of various purines, pyrimidines and derivatives on adipose-tissue phosphodiesterase 来自 NCBI 喜欢 0 阅读量: 16 作者:DG Peers,JI Davies 摘要: Highest blood concentrations of acetoacetate are found at 5 days of age, after which time the concentration falls...
Pyrimido[5,4-d]pyrimidines derivatives as irrevers 优质文献 相似文献 参考文献Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine790 → Methionine790 Mutant
发明人: WJ Coates 被引量: 13 摘要: This invention relates to pyrimidopyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 7-cyclopropylamino-4-oxo-2-(2-propoxyphenyl)-3,4- dihydropyrimido[4,5-d] pyri midine.收藏...
Magda N. Nasr and,Magdy M. Gineinah 摘要: A series of 7-amino- and 7-oxo-5-aryl-6-cyanopyrido[2, 3-d]pyrimidines, 4 and 11, respectively, and pyrimido [5′, 4′:5, 6]pyrido[2, 3-d]pyrimidine derivatives 6 and 7 was synthesized and investigated as antiviral agents. Different ...
EP0635498 1995-01-25 Quinazoline derivatives and their use as anti-cancer agents EP0635507 1995-01-25 Tricyclic derivatives and their use as anti-cancer agents EP0682027 1995-11-15 Pyrrolopyrimidine derivatives with antiproliferative action EP0787722 1997-08-06 Substituted quinazoline derivatives TW2701...
The importance of pyrimidine and quinazoline heterocyclic compounds in biological systems is also emphasized, since two of the four DNA bases are pyrimidine derivatives, and many modern pharmaceutical agents contain either pyrimidine or quinazoline fragments. Several examples of biologically important ...
- Pyrido-thieno-pyrimidine or pyrido-furo-pyrimidine derivatives of formula (I) (including their solvates, salts, prodrug formulations, active metabolites and tautomers) are new. - Y = O or S; - R1 and R3 = H; 1-12C alkyl, 2-12C alkenyl, 2-12C alkynyl, benzyl, (1-12C) alkylacyl,...
Further substitution of compounds (2a,b) yielded the N 3 -Substituted pyrimidine derivatives (7a-e). Desulphunisation of each of compounds (2a,b) with ben- zhydrazide resulted in the formation of 2-(2-benzoylhydrazino)- py- rimidine derivative (9) , which could be converted into the ...
Microwave-enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides Botta, "Microwave- enhanced Sonogashira coupling reaction of substituted pyrimidinones and pyrimidine nucleosides," Tetrahedron Let- ters, vol. 44, no. 51,... E Petricci,M Radi,F Corelli,... - 《...