采用量子化学密度泛函理论(DFT)方法,在B3LYP/6-31G*基组水平上对吡啶并嘧啶类衍生物进行了几何构型优化和电子结构计算。 The optimized geometries and electronic structures of pyridopyrimidines derivatives...
Pyrimido[5,4-d]pyrimidines derivatives as irrevers 优质文献 相似文献 参考文献Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine790 → Methionine790 Mutant
发明人: WJ Coates 被引量: 13 摘要: This invention relates to pyrimidopyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 7-cyclopropylamino-4-oxo-2-(2-propoxyphenyl)-3,4- dihydropyrimido[4,5-d] pyri midine.收藏...
Derivatives of fluorophenyl-triazines and pyrimidines, their preparation and their application as drug Novel fluorophenyl-triazine and pyrimidine derivatives of general formula (I), wherein R1 is an amino group, a 1-piperazinyl group or a 4-alkylpiperazin-1-... J Torrens,CJ Frigola 被引量: 0...
1453729 Phenolic antioxidants containing triazine or pyrimidine rings SANDOZ Ltd 14 Nov 1973 [15 Nov 1972] 52771/73 Heading C3P [Also in Division C2] Novel anti-oxidants for polymeric material, e.g. polypropylene, are pyrimidine and striazine derivatives of Formula I wherein R is a group of ...
EP0602851 1994-06-22 Quinazoline derivatives EP0635498 1995-01-25 Quinazoline derivatives and their use as anti-cancer agents EP0635507 1995-01-25 Tricyclic derivatives and their use as anti-cancer agents EP0682027 1995-11-15 Pyrrolopyrimidine derivatives with antiproliferative action EP0787722 1997-08...
In silico design, synthesis and anti-HIV activity of quinoline derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) A series of quinoline derivatives has been designed, synthesized and screened for their anti-HIV properties. The drug-like properties of compounds were eva... VK ...
[1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by the following general formula (I) or pharmacologically acceptable salts thereof which show an adenosine A2A receptor antagonism and are useful in treating and/or preventing vari... YOSHIHISA KUWANA,JUNICHI SHIMADA,HIRONORI IMMA,... 被引...
Table 1.Synthesis of benzo[6,7]chromeno[2,3-d]pyrimidine derivatives under one-pot solvent- and catalyst-free conditions. Interestingly, we can note that the nature of the aryl group can have a significant impact on the yield of the reaction. ...
To further these studies, we report herein the synthesis of new 4-substituted thieno[3,2-d]pyrimidine derivatives and their in vitro activities against the blood stage of P. falciparum and the liver stage of a rodent malaria model, P. berghei. To bring chemical diversity in position 4 of ...