precursors,thepurineandpyrimidinenucleosides,through denovosynthesisfromsimplercarbonandnitrogencom- poundsandthroughutilizationofsalvagepathways.Inthe pyrimidinesalvagepathway,thymidinekinase(TK;ATP: thymidine5'-phosphotransferase;EC2.7.1.21)catalyses,in thepresenceofATPandadivalentcation,thephosphory- ...
【答案】：嘧啶核苷酸的补救合成途径：利用体内游离的嘧啶或嘧啶核苷，经过简单的反应过程，合成嘧啶核苷酸，称为嘧啶核苷酸的补救合成途径。
PyrimidinesRNA synthesisDuodenumCell renewalMouse CD1 (C. RiverRNA synthesis was examined by radioautography in mouse doudenal epithelium using 3 H-uridine as a tracer of the salvage pathway and 3 H-orotic acid as a tracer of the de novo pathway. The incorporation of the two precursors was ...
20.3.2.3.1 Potential Inhibitors of Pyrimidine Salvage in T. gondii Genetic studies on the pyrimidine salvage pathway have been performed in T. gondii. In early mutagenesis and biochemical studies UPRT was demonstrated to be dispensable and therefore UPRT could be used as a target for genetic inact...
17 The synthesis of NAD+ is in turn catalysed by two major metabolic pathways: the de novo pathway from tryptophan, and the salvage pathway that involves biosynthesis from other NAD+ precursors.18 The synthesis of NAD+ via the salvage pathway is conducted by precursor enzymes NAMPT (nicotinamide...
Among the enzymes involved in pyrimidine synthesis, the half-life of UCK2 was most strongly altered by the status of mTORC1 activity. Thus, this result implies a previously unknown role of mTORC1 in the pyrimidine salvage pathway. In this study, we report that mTORC1 regulates pyrimidine ...
Both UMP and G- 1-P support the generation of nucleotides, either directly by converting UMP into both pyrimidines dCTP and dTTP or indirectly though the TCA cycle and the pentose phosphate pathway (PPP). Glucose metabolism is known to be regulated by cMYC, resulting in the activation of ...
The catalytic properties and the regulation of the enzymes involved in the reutilization of preformed purines and pyrimidine bases for nucleotide synthesis in mammalian tissues are reviewd. The developmental patterns of these enzymes in fetal and newborn animals are reported and the physiological signifi...
嘧啶核苷酸补救合成途径(salvage pathway of pyrimidine)【答案】:嘧啶核苷酸的补救合成途径:利用体内游离的嘧啶或嘧啶核苷,经过简单的反应过程,合成嘧啶核苷酸,称为嘧啶核苷酸的补救合成途径。
, Purine and Pyrimidine Metabolism in Man, V, Part B, pp. 371-376. New York: Plenum Pubi. Co., 1986.Natsumeda, Y.; Ikegami, T.; Weber, G. Purine synthetic capacities of de novo and salvage pathways in rat hepatoma 3924A cells. Adv. Exp. Med. Biol. 1986, 195, 371-376....