Figure: Metabolic pathways are a series of reactions catalyzed by multiple enzymes. Feedback inhibition, where the end product of the pathway inhibits an upstream step, is an important regulatory mechanism in cells. Image Source:OpenStax Biology. End-product inhibition is a cellular control mechanism...
Several metabolites of skatole has been identified, however the role of these metabolites in the inhibition of the skatole metabolizing enzymes are not documented. Using microsomes from pigs and fish, we determined the ability of several skatole metabolites to inhibit CYP1 A, CYP2A19 and CYP2E1...
Metabolism - End Product, Inhibition, Regulation: A biosynthetic pathway is usually controlled by an allosteric effector produced as the end product of that pathway, and the pacemaker enzyme on which the effector acts usually catalyzes the first step tha
the activation or inhibition of AKT (Wang et al.2022a,b) in response to the AGE-RAGE interaction remains controversial. Li et al. (Li et al.2012) reported the inhibition of AKT upon AGE stimulation in human neuroblastoma SK-N-SH cells and embryonic hippocampal neurons (Li et al.2013), ...
Next, we discovered that the repair of DSBs resulted from gamma ray irradiation was delayed by cAMP signaling through inhibition of NHEJ in NSLC cells. The discovery is grounded in the results that cAMP signaling inhibited the recruitments of XRCC4 and DNA ligase IV, the essential enzymes for ...
The results showed that even though some ammonium salts and casamino acids can depress NIR level under certain conditions this inhibition cannot be interpreted in terms of direct end-product inhibition of NIR synthesis because their effects were dependent on the character (anion) and toxicity of the...
Richardson, M. A.Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives., 3406–3409 (2015). PubMedPubMed CentralGoogle Scholar Nagayama, D.High hemoglobin glycation index is associated with increased systemic arterial stiffness independent of hyperglycemi...
Inhibition of human endothelial cell nitric oxide synthesis by advanced glycation end-products but not glucose: relevance to diabetes Clinical Science (London), 109 (2005), pp. 439-446 View in ScopusGoogle Scholar [54] H. Vlassara Advanced glycation end-products and atherosclerosis Annals of Medic...
the inhibition of oxidative stress-producing enzymes such as CYP2E1137,181and NADPH oxidase274is an option to prevent the formation of AGE adducts and AGE-associated cellular and/or organ damage. For instance, taking naturally occurring CYP2E1 inhibitors (e.g., diallyl disulfide in garlic273,27...
MAG genes related to nitrogen cycle enzymes were identified by DIAMOND [45] search (e value threshold 10−5, minimum 50% identity) against the marker proteins database. To remove spurious homologs, all candidate genes were used in a second DIAMOND search (e value threshold 10−4) against...