This inhibition is involved in the regulation of how much of the end products to be produced. Most biochemical processes are complex and require multiple enzymes to produce the desired product. In such processes, end-product inhibition acts on the first enzyme of the process. ...
Several metabolites of skatole has been identified, however the role of these metabolites in the inhibition of the skatole metabolizing enzymes are not documented. Using microsomes from pigs and fish, we determined the ability of several skatole metabolites to inhibit CYP1 A, CYP2A19 and CYP2E1...
In order to further verify AGEs inhibition, we investigated the amount of fructosamine formed using a colorimetric assay. Fructosamine is an Amadori product formed by the glycation of amino acid via Schiff’s base (Singh et al., 2001). This assay is a colorimetric test that determines the degr...
Notably, the inhibition of the fundamental protein GAPDH and the disruption of mitochondrial electron transfer chains are particularly significant. Excessive levels of ROS can attack PUFA-PLs, creating lipid peroxide-derived agents that contribute to the RCS pool. Moreover, the overproduction of ROS ...
Caballero F, Gerez E, Batlle A, Vazquez E (2000) Preventive aspirin treatment of streptozotocin induced diabetes: blockage of oxidative status and revertion of heme enzymes inhibition. Chem Biol Interact 126:215–225 Article CAS Google Scholar Cai W, Cao QD, Zhu L et al (2002) Oxidative ...
At high levels both enzymes are responsible for rapid degradation of collagen type II, resulting in osteoarthritis. Inhibition of Stat-3 shows a reduction of AGE-induced loss of collagen II [158]. In contrast, Huang et al. showed an AGE-mediated increase of collagen IV production in rat ...
(6-O-feruloyl)-β-d-glucopyranoside were isolated as active principles and related compounds [12]. However, little is known about the biologically active compounds of majorana as a medicinal plant. In this study, the aim is to investigate the AGEs inhibition capacity of extracts from the ...
Werner N, Priller J, Laufs U, Endres M, Bohm M, Dirnagl U, Nickenig G: Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arterioscler Thromb Vasc Biol. 2002, 22 (10): 1567...
Pharmacological inhibition of DNA-repair pathways as an approach for the potentiation of chemo- and radio-therapeutic cancer treatments has attracted increasing levels of interest in recent years. Inhibitors of several enzymes involved in the repair of DNA strand breaks are currently at various stages ...
Possible implication in the inhibition of advanced glycation end product formation Biochem Pharmacol, 58 (1999), pp. 1765-1773 View PDFView articleView in ScopusGoogle Scholar 97 O.R. Kinsky, T.L. Hargraves, T. Anumol, et al. Metformin scavenges methylglyoxal to form a novel imidazolinone ...