Metabolism - End Product, Inhibition, Regulation: A biosynthetic pathway is usually controlled by an allosteric effector produced as the end product of that pathway, and the pacemaker enzyme on which the effector acts usually catalyzes the first step tha
A compound that enhances homology-directed repair in CRISPR editing leads to genome instability. Grégoire Cullot Eric J. Aird Jacob E. Corn ResearchOpen Access27 Nov 2024Nature Biotechnology P: 1-5 EZH2 inhibition sensitizes MYC-high medulloblastoma cancers to PARP inhibition by regulating NUPR1-...
The receptor for advanced glycation end-products (RAGE) modulates the pathogenesis of acute respiratory distress syndrome (ARDS). RAGE inhibition attenuated lung injury and restored alveolar fluid clearance (AFC) in a mouse model of ARDS. However, clinic
the activation or inhibition of AKT (Wang et al.2022a,b) in response to the AGE-RAGE interaction remains controversial. Li et al. (Li et al.2012) reported the inhibition of AKT upon AGE stimulation in human neuroblastoma SK-N-SH cells and embryonic hippocampal neurons (Li et al.2013), ...
Inhibition mechanism of mango vinegar on protein-AGEs digestion in vitro gastrointestinal environment 2023, LWT Citation Excerpt : Although there was still no specific toxicity limit for AGEs, the internal circulation of AGEs and dietary AGEs were found to be significantly correlated in both human and...
Cadaverine is an important C5 platform chemical with a wide range of industrial applications. However, the cadaverine inhibition on the fermenting strain limited its industrial efficiency of the strain. In this study, we report an engineered Escherichia coli...
DCN (Decorin) is a multifunctional molecule that regulates cell adhesion, migration and invasion. DCN actions at the fetal-maternal interface include inhibition of placental invasion of the pregnant uterus and uterine arterial remodeling. Lalaet al[53] reviewed its role and reported thatDCNover-expres...
Inhibition of the AGE-RAGE complex by antagonists, such as linagliptin, proved to have a potent protective mechanism from renal damage in diabetes [82]. Diabetes is known to cause vascular permeability and vascular dysfunction was detected on day 10 of exogenous administr...
DNA double-strand breaks (DSB) are formed by various exogenous and endogenous factors and are repaired by homologous recombination and non-homologous end joining (NHEJ). DNA-dependent protein kinase (DNA-PK) is the principal enzyme for NHEJ. We explored
a similar role in adipocytes44,45. In contrast, RhoA and ROCK promote insulin resistance in myocytes46and pancreatic beta cells47. Other data demonstrate that Rho signaling is upregulated in adipose and other tissues in murine and human obesity48,49,50,51, and that Rho inhibition improves ...