(redirected from end-product inhibition)Also found in: Thesaurus, Medical, Legal, Encyclopedia. in·hi·bi·tion (ĭn′hə-bĭsh′ən, ĭn′ə-) n. 1. The act of inhibiting or the state of being inhibited. 2. Something that restrains, blocks, or suppresses. 3. Psychology ...
In populations with chronic disease, skin autofluorescence (SAF), a measure of long-term fluorescent advanced glycation end-products (AGEs) accumulation in body tissues, has been associated with vascular endothelial function, measured using flow-mediated dilation (FMD). The primary aim of this study...
Moreover, we demonstrated inhibition of mineralization and the suppression of active LOX protein in the AGE-BSA-treated osteoblast cells. These results suggest that the accumulation of AGEs in osteoblasts of ROD might suppress osteoblast differentiation and inhibit LOX activation. This could lead to a...
(Supplementary Table48). However, similar to the previous discussion on the diol inhibition mechanism on Cu/TEMPO catalytic system, Result Interpreter based on GPT-4 base model lacks the in-depth chemistry knowledge to propose the specific roles of14acting both as a nucleophile and a base ...
The relative roles of advanced glycation, oxidation and aldose reductase inhibition in the development of experimental diabetic nephropathy in the Sprague-Dawley rat. Diabetologia. 1995;38:387-394. [PubMed] [Cited in This Article: 1] 69. Oldfield MD, Bach LA, Forbes JM, Nikolic-Paterson D...
The advantage of dead-end filtration is high product recovery and simple operation. The filter cartridges (depth filters), however, cannot be backwashed or cleaned because of internal pore blockage; instead, they are discarded. In the case of charged cartridges, the separation is based on two ...
(ii) Inhibition of membrane recruitment of Atg16L complex leads to a defect in the lipidation reaction and (iii) Atg16L complex artificially localized to the plasma membrane catalyzed the lipidation reaction there.24 Thus, the Atg16L complex is competent for the recruitment of the activated E2...
For inhibition of LINE1's RT activity, HEK293 cells were mock-treated or treated with 30-Azido-30-deoxythymidine and 20, 30-dideoxyinosine (1 mg ml À 1 each)19 for 48 h, and the NE was used for RNA-templated repair as described above. The reaction buffer also contained 30-Azido-...
contacting said stable protein-sugar post-Amadori advanced glycation end-product intermediates with an inhibitor candidate; identifying effective inhibition by monitoring the formation of post-Amadori AGEs after release of the stable protein-sugar post-Amadori advanced glycation end-product intermediates from...
Second, the survival signaling pathways of the actual therapeutic value of pinocembrin have been demonstrated through inactivation of RAGE-dependent signaling pathways and inhibition of mitochondrion-mediated apoptosis against Aβ-mediated neurotoxicity. Third, RAGE was used as a therapeutic target for ...