suggesting a model in which dissociation of tau results in MT instability. It should be noted, however, that the precise hierarchy of events during the onset of AD remains unclear
2.1.4. Inactivation of PTEN The loss of tumor-suppressor protein PTEN, especially in combination with inactivation of RB1 and/or TP53, has been recognized as one of the signs of aggressive variant PCa (AVPC) [39,40]. PTEN inactivation is present in approximately 20% of primary tumors and...