在 18 对原发性结肠癌肿瘤和匹配的肝转移瘤中,H19表达在转移瘤中显着更高。总之,这些结果表明H19表达在 EMT 期间通过 CpG 甲基化被抑制,但在转移定植期间强烈诱导。因此,H19可能起到早期结肠癌进展的抑制因子和晚期结肠癌进展的促进剂的作用。 图6:H19 lnc...
when DNA methylation also plays a key role in the epigenetic-based regulation of gene expression. Profiling cellular or fresh tissue genomic DNA samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also help provide further insights into...
上皮细胞-间质转化甲基化PCR芯片用于研究这个过程中下调的22基因的启动子甲基化状态。EMT和相互间质上皮过渡(MET)是参与肿瘤的转移和干细胞分化和发育的关键步骤。利用这些芯片分析细胞或新鲜组织基因组DNA样本有助于关联CpG岛甲基化状态与生物表型。结果也可能有助于进一步洞察EMT在肿瘤转移及干细胞分化和发展中的作用...
G. Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J. Biol. Chem. 275, 2727–2732 (2000). CAS PubMed Google Scholar Lombaerts, M. et al. E-cadherin transcriptional ...
and its expression is critical for self-renewal and pluripotency of ESCs, as well as for efficient iPSC reprogramming [197] (Fig.3). Likewise, pluripotent stem cells preferentially express MBD2c, an AS variant of the methyl-CpG binding protein MBD2a that is mainly expressed by differentiated ce...
Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG . Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression.J Biol Chem2000;275: 2727–2732. ...
et al. Defective expression of transforming growth factor β receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin. Cancer Res. 10, 2359–2367 (2004). Article CAS Google Scholar Xu, J. B. et al. Defective expression of transforming growth ...
Using Infinium HumanMethylation27K BeadChip array and pyrosequencing, we further analyzed the CpG methylation levels at the DDR1 promoter in EOC cells and found that the CpG methylation levels of DDR1 promoter correlated negatively with the expression of DDR1 along the EMT spectrum. Therefore, EMT...
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The binding of ZEB1 to the two E-box elements within the upstream CpG-rich region of the ESR1 promoter represses ERα expression39. In contrast, our ERα reporter construct contains an ERE and its ERα-mediated expression is significantly boosted by ZEB1. We also demonstrate that a VEGFA ...