在 18 对原发性结肠癌肿瘤和匹配的肝转移瘤中,H19表达在转移瘤中显着更高。总之,这些结果表明H19表达在 EMT 期间通过 CpG 甲基化被抑制,但在转移定植期间强烈诱导。因此,H19可能起到早期结肠癌进展的抑制因子和晚期结肠癌进展的促进剂的作用。 图6:H19 lnc...
CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. Cancer Res. 2009;69(12):5194–201. https://doi.org/10.1158/0008-5472.CAN-08-3694. Article PubMed CAS Google Scholar Di ...
et al. Defective expression of transforming growth factor β receptor type II is associated with CpG methylated promoter in primary non-small cell lung cancer. Clin. Cancer Res. 10, 2359–2367 (2004). Article CAS Google Scholar Xu, J. B. et al. Defective expression of transforming growth ...
1). Methylation of ZNF471 promoter of SIL (LSIL and HSIL) at specific CpG sites (positions: 6, 7, and 15 to 19) was also different from normal and tumor tissues (Fig. 1c–e). Fig. 1 DNA methylation analysis of the ZNF471 promoter. ZNF471 expression is downregulated by promoter ...
Burn Wound Management in Prolonged Field Care (CPG ID: 57) 15個詞語 marksullivan0529 預覽 EMT/AEMT S/S to pass NREMT 133個詞語 jiggelyfluff2 預覽 Pharm III Final Exam Review 69個詞語 Kyleigh_Storrs34 預覽 Spinal Cord Injuries 91個詞語 mollybaxtercalvin 預覽 chapter 23 First Aid Provider...
The binding of ZEB1 to the two E-box elements within the upstream CpG-rich region of the ESR1 promoter represses ERα expression39. In contrast, our ERα reporter construct contains an ERE and its ERα-mediated expression is significantly boosted by ZEB1. We also demonstrate that a VEGFA ...
Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG . Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression.J Biol Chem2000;275: 2727–2732. ...
J. Pers. Med., 11 (11) (2021) Google Scholar [99] R. Luo, J. Song, X. Xiao, Z. Xie, Z. Zhao, W. Zhang, S. Miao, Y. Tang, L. Ran Identifying CpG methylation signature as a promising biomarker for recurrence and immunotherapy in non-small-cell lung carcinoma Aging, 12 (14...
27 In our study, we found that miR-148a-3p surrounding CpG islands were hypermethylated in bladder cancer and that treatment with 5-aza-CdR induced miR-148a-3p overexpression in bladder cancer. We confirmed that DNMT1 was a direct miR-148a-3p target and that miR-148a-3p expression ...
Changes in the degree of methylation, both within CpG DNA islands and histone proteins, have been observed in cancer with different expression levels of MMP9. The extensive CpG islands present in the coding region are epigenetically repressed in glioma cells. In breast carcinoma cells, the ...