Furthermore, we demonstrated that DNMT1 regulated the MEG3 expression via altering the CpGs methylation level of MEG3 promoter in TGF-β1-induced renal fibrosis. In addition, we further revealed that miR-185 could regulated the DNMT1 expression and thus, modulating the MEG3 in TGF-β1-...
In our samples, DNA methylation (promoter and individual CpGs) levels between −590 to −228 were significantly higher in tumor tissues when compared with normal and SIL samples (P<0.05; Fig. 1a–d). Analysis of the public datasets revealed that the ZNF471 gene promoter is significantly ...
The coding region CpGs are located from nucleotides 374693 to 374845 on chromosome 1 (strand (+), RefSeq accession no. AC_000133.1). The filled rectangle represents the coding region of mir-200a in relation to sequencing results. Arrows represent miR-200B/A/429 relative locations on chromosome...
CLL cases exhibit vast interpatient differences in intratumor methylation heterogeneity, with genetically clonal cases maintaining low methylation heterogeneity and up to 10% of total CpGs in a monoallelically methylated state. Increasing methylation heterogeneity correlates with advanced genetic subclonal ...