Ma K, Zhang T, Zhang L, Mao X, Liu H, Xing P, Liang N. Distribution of ALK Fusion Variants and Correlation with Clinical Outcomes in Chinese Patients with Non-Small Cell Lung Cancer Treated with Crizotinib. Target Oncol. 2019
对于基因检测报告的分析和解读，正规的基因检测公司会给出明确的指导。#肺癌# 参考文献：Zhang SS, et al., Going beneath the tip of the iceberg. Identifying and understanding EML4-ALK variants and TP53 mutations to optimize treatment of ALK fusion positive (ALK+) NSCLC, Lung Cancer (2021)
The H2228 cell line contains 3a and 3b variants and is described as having cyctostatic response to ALK inhibition as opposed to apoptotic. In a study of 31 NSCLC patients with EML4-ALK rearrangements, 4/5 patients with the 3a variant showed a partial response while 1 showed progressive ...
duration of response, and progression-free survival (PFS) by blinded independent central review based on EML4::ALK variants and ALK with or without TP53 or other mutation status.
(IHC) or real-time polymerase chain reaction (RT-PCR), 63 patients were confirmed as ALKrearrangement by next-generation sequencing (NGS), including 55 cases of stage I-III and 8 cases of stage IV. Medical records w...
EML4-ALK融合基因包括多种变异体(variants),其 中变异体l(variant 1或VI)和变异体3(variant 3或V3)的检出率最高。同时,EML4-ALK 抑制剂为肺癌的个性化治疗提供了新的途径。[0003] 当前国内外广泛使用的分子生物学检测EML4-ALK融合基因的方法中,荧光原位 杂交技术(FISH)操作复杂,而且不能区分不同的变异体;荧光...
Fig. 5: Condensation and suppression of RTK signaling are common properties among EML4-ALK variants. A Three common oncogenic variants of EML4-ALK (Variants 1–3) share a common ALK fragment but differ in the lengths of the EML4 domain. B Expression of mCh-EML4-ALK(V1/2/3) in GRB2:mN...
本研究通过在断裂点的上下游分别设计引物,且为了避免在KNA提取过程中D N A的污染，对每对引物都进行跨外显子设计，旨在寻找一种快速 有效成本效低的/1认融合基因检测方法，为患者提供更加 准确的诊断结果。1材料与方法 1.1材料收集东部战区总医院病理科2019-06—2020-06 采用厦门艾德公司法检测出NSCLC AW M-/...
Currently, eight EML4-ALK variants are generally recognized with a number (1, 2, 3a/b, 4′, 5a/b, 5′, 7, 8) with EML4-ALK variants 1 and 3 being the two most common variants accounting for 75–80 % of the total EML4-ALK variants. Preclinical, retrospective analyses of ...
要确定染色体重排,最简单的方法是根据 HAPLOTYPES 视图和使用 STRUCTURAL VARIANTS 视图确定的融合绘制野生型基因组织示意图。最可能的融合机制是 2 号染色体 p 臂末端与 5 号染色体 q 臂末端的相互易位,如下所示。 文献八、 文献九...