Gadgeel SM, Cheema P, Pavlakis N, de Marinis F, Cho BC, Zhang L, Moro-Sibilot D, Liu T, Bordogna W, Balas B, Müller B, Shaw AT. Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of ...
EML4—ALK融合基因Lung neoplasmsEML4-ALK fusion geneEML4—ALK融合基因是在非小细胞肺癌(NSCLC)中发现的新分子分型,由2号染色体上两个基因片段倒位融合而成,目前发现的9种亚型均具有恶化致癌能力。该融合基因在腺癌、不吸烟或少吸烟和缺少表皮因子生长受体(EGFR)及结直肠癌基因(KRAS)变异的患者中检出率较高。该...
Sustained Response to Brigatinib in an Aggressive Relapsing Atypical Pituicytoma With ELM4-ALK Fusion. JCO Precis Oncol. 2024 Nov;8:e2400381. doi: 10.1200/PO-24-00381. Epub 2024 Nov 22. PMID: 39576952; PMCID: PMC11608595. 发布于 2024-12-19 17:01・IP 属地江苏...
Moser PO, Rigau V, Goze C, Ringeard I, Favier V, Darlix A, Boetto J. Sustained Response to Brigatinib in an Aggressive Relapsing Atypical Pituicytoma With ELM4-ALK Fusion. JCO Precis Oncol. 2024 Nov;8:e2400381. doi: 10.1200/PO-24-00381. Epub 2024 Nov 22. PMID: 39576952; PMCID...
1. Soda M, Choi YL, Enomoto M, et al: Identification of the transforming EML4-ALK fusion gene in non–small-cell lung cancer.Nature2007,448(2):561-566 2. Wong DW, Leung EL, So KK, et al: The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsm...
外周血检测到an EML4-ALK fusion gene. KRAS Q61H mutation, NF1 Q20 and TP53 splice site (783-2A>G),还检测到临床未明的ALK L1319V mutation。患者更换了ceritinib,治疗三个月,尽管CEA水平暂时下降,但疾病仍进展为转移性肝肿瘤扩大和腹膜癌。继续换用了brigatinib,该患者在确诊结肠癌22个月后死于肝功能...
[4] H Hatanaka. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. 《Nature》, 2007, 448(7153):561-566. [5] A Yoshida. Bright-field dual-color chromogenic in situ hybridization for diagnosing echinoderm microtubule-associated protein-like 4-anaplastic lymphoma...
4. .Guo W, Liang J, Zhang D, Huang X, Lv Y. Lung adenocarcinoma harboring complex EML4-ALK fusion and BRAF V600E co-mutation responded to alectinib. Medicine (Baltimore). 2022 Oct 7;101(40):e30913. 5. Shi R...
ALK和EGFR哪个恶性高ALKEML4融合变异Fusion eml4alk融合是好事还是恶性ALK突变一般是晚了吗 ALK突变V1V2V3的区别alk罕见点突变 ALK检测结果EML4–alkALK检测结果EML4–alk融合 靶向是什么意思? 怎么治疗 问靶向治疗定义 答靶向治疗是指针对靶向药物在肿瘤细胞上进行针对性治疗的一种手段,是目前治疗肿瘤最有效、最先进的...
Right GeneALK 1st of two Breakpoints EML4(E6)-ALK(E20) Fusion Left Breakpoint chr2:42491871:+ Right Breakpoint chr2:29446394:- Cosmic ID COSF411 2nd of two Breakpoints EML4(E6)-ALK(E20) Fusion Left Breakpoint chr2:42492091:+ Right Breakpoint chr2:29446394:- ...