Elias, Breelyn A. Wilky, Lynn E. Heasley, Kurtis D. Davies, Novel PLEC-EML4-ALK Double Fusion Underlying Crizotinib Resistance in a Metastatic Inflammatory Myofibroblastic Tumor – Case Report,JTO Clinical and Research Reports,doi.org/10.1016/j.jtocr. 发布于 2025-02-08 09:10・IP 属地江苏...
Gadgeel SM, Cheema P, Pavlakis N, de Marinis F, Cho BC, Zhang L, Moro-Sibilot D, Liu T, Bordogna W, Balas B, Müller B, Shaw AT. Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of ...
^M. Soda, Y. L. Choi, M. Enomoto, et al., “Identifification of the Transforming EML4-ALK Fusion Gene in Nonsmall-Cell Lung Cancer,” Nature 448 (2007): 561–566. ^C. H. Chuang, H. L. Chen, H. M. Chang, et al., “Systematic Review and Network Meta-Analysis of Anaplastic ...
As the EML4-ALK fusion protein promotes carcinogenesis in lung cells, much attention has been paid to it, leading to the development of therapies for patients with NSCLC. These therapies include ALK tyrosine kinase inhib...
EML4—ALK融合基因Lung neoplasmsEML4-ALK fusion geneEML4—ALK融合基因是在非小细胞肺癌(NSCLC)中发现的新分子分型,由2号染色体上两个基因片段倒位融合而成,目前发现的9种亚型均具有恶化致癌能力。该融合基因在腺癌、不吸烟或少吸烟和缺少表皮因子生长受体(EGFR)及结直肠癌基因(KRAS)变异的患者中检出率较高。该...
Figure 3. EML4-ALK V1 [I1171N/L1198H]]/BaF3 Fusion Figure 4. EML4-ALK V1 [I1171N/L1198H]]/BaF3 L1198H Figure 6. EML4-ALK V1 [I1171N/L1198H]]/BaF3 I1171N 2. Anti-proliferation assay Figure 7. CTG Proliferation Assay of EML4-ALK V1 I1171N/L1198H BaF3(C1).相关...
IV. Representative Data 1. Sanger of EML4-ALK V1 [I1171S]/BaF3 Figure 2. EML4-ALK V1 [I1171S]/BaF3 Fusion Figure 3. EML4-ALK V1 [I1171S]/BaF3 I1171S 2. Anti-proliferation assay Figure 4. CTG Proliferation Assay of BaF3 EML4-ALK V1 [l1171S] (C1).相关...
ALK和EGFR哪个恶性高ALKEML4融合变异Fusion eml4alk融合是好事还是恶性ALK突变一般是晚了吗 ALK突变V1V2V3的区别alk罕见点突变 ALK检测结果EML4–alkALK检测结果EML4–alk融合 靶向是什么意思? 怎么治疗 问靶向治疗定义 答靶向治疗是指针对靶向药物在肿瘤细胞上进行针对性治疗的一种手段,是目前治疗肿瘤最有效、最先进的...
Sustained Response to Brigatinib in an Aggressive Relapsing Atypical Pituicytoma With ELM4-ALK Fusion. JCO Precis Oncol. 2024 Nov;8:e2400381. doi: 10.1200/PO-24-00381. Epub 2024 Nov 22. PMID: 39576952; PMCID: PMC11608595. 发布于 2024-12-19 17:01・IP 属地江苏...
[4] H Hatanaka. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. 《Nature》, 2007, 448(7153):561-566. [5] A Yoshida. Bright-field dual-color chromogenic in situ hybridization for diagnosing echinoderm microtubule-associated protein-like 4-anaplastic lymphoma...