参考文献: Shubham Pant et al, Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial, Nature Medicine, (2024).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088885/ [3]Guo Z,et al. Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer[J]. NPJ Precision On...
with the goal of promoting durable cancer immunosurveillance in patients. Elicio’s ELI-002 lead program is an off-the-shelf vaccine candidate targeting the most common KRAS mutations, which drive approximately 25% of all solid tumors. ELI-002 is being studied in an ongoing, random...
Background Successful advancement of vaccine strategies for the treatment of solid tumors has been limited due to the limitations of vaccine delivery platforms and inadequate immune responses. ELI-002 immunotherapy uses Amphiphile (Amph) lymph node targeting to improve the potency of vaccination. Amph-...
“Lymph Node Targeted, mKRAS-specific Amphiphile Vaccine in Pancreatic and Colorectal Cancer: The phase 1 AMPLIFY-201 Trial”, details expanded and updated results originally presented at the 2023 American Society of Clinical On...
Craig E. Devoe, MD, MS, discusses next steps for assessing the ELI-002 7P vaccine in patients with MRD–positive, KRAS-mutant PDAC and CRC.
ELI-002 is an investigational AMP cancer vaccine that targets cancers driven by mutations in the KRAS gene. The vaccine combines 2 components: AMP-modified mutant KRAS peptide antigens and ELI-004, an AMP-modified CpG oligodeoxynucleotide adjuvant, which can be administered subcutaneously.1 The 2-...
[5]https://oncologypro.esmo.org/meeting-resources/esmo-congress-2024/an-exploratory-study-to-assess-the-safety-immunogenicity-and-preliminary-anti-tumor-activity-of-the-ebv-mrna-vaccine-wgc-043-injection-in-patie [6]https://www.esmo.org/oncology-news/proof-of-concept-for-the-safety-and-immuno...
[2]https://www.curetoday.com/view/first-patient-dosed-in-phase-2-cancer-vaccine-trial 编者按 如果您希望了解更多癌症等重大、复杂疾病的海外前沿研究成果、药物、疗法信息,请扫描下方二维码联系我们,盛诺一家可以为您提供专业的就医...