Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory ...
Milosavljevic D, Brücke T, Bayer P, Hübl W: Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis - PresslauerPresslauer S, Milosavljevic D, Brucke T, Bayer P, Hubl W: Elevated levels of kappa free light chains in CSF support the diagnosis of ...
Isotype variants were based on human IgG1 (G1m(f) isotype) and IgG3 (P01860), all variants were co-expressed with kappa light chain. Gene constructs for heavy and light chains were designed to include a cleavable signal sequence for secretion and were flanked by restriction sites to allow...
C. NF-[kappa]B and STAT3 Inhibition as a Therapeutic Strategy in Psoriasis: In Vitro and In Vivo Effects of BTH. J Invest Dermatol 133, 2362–2371 (2013). 30. Liang, J. et al. Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of ...
High sensitivi- ty and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis. J Neuroimmunol 2014; 276:175-9 (PMID: 25146968).G. Hassan-Smith, L. Durant, A. Tsentemeidou, L.K. Assi, J.M. Faint, S. Kalra, M.R. Douglas, S.J. Curnow, ...
Free light chainsHigh amount of polyclonal free light chains (FLC) are reported in systemic autoimmune diseases (SAD) and we took advantage of the PRECISESADS study to better characterize them. Serum FLC levels were explored in 1979 patients with SAD (RA, SLE, SjS, Scl, APS, UCTD, MCTD) ...
Kappa and lambda free light chains of immunoglobulins and beta2-microglobulin were not associated with changes in systemic disease activity. An elevated serum BAFF level was significantly more frequently associated with the occurrence of a new moderate/high domain at 1 and 3 years (20.0% vs 7.7%...
Results: Bone marrow trephines of 156 histologically proven DLBCL cases at initial diagnosis were assessed on routine histology, and immunohistochemistry using two T-cell markers (CD45RO and CD3), two B-cell markers (CD20 and CD79a) and kappa and lambda light chains. Raw flow cytometry data ...