Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory ...
Presslauer S, Milosavljevic D, Brucke T, Bayer P, Hubl W et al. Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J Neurol. 2008; 255: 1508-1514 doi: 10. 1007/s00415-008-0954-z PMID: 18685917...
High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis. J Neuroimmunol 2014;276:175-9.Hassan-Smith, G., Durant, L., Tsentemeidou, A., Assi, L.K., Faint, J.M., Kalra, S., et al., 2014. High sensitivity and specificity...