Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels > or = 1.53 microg/mL predicted progression to need for ambulatory ...
Milosavljevic D, Brücke T, Bayer P, Hübl W: Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis - PresslauerPresslauer S, Milosavljevic D, Brucke T, Bayer P, Hubl W: Elevated levels of kappa free light chains in CSF support the diagnosis of ...
Numerous studies have demonstrated elevated kappa free light chains (KFLCs) in CSF of multiple sclerosis (MS) patients. However, so far only small cohorts have been examined, and generally only through qualitative KFLCs analysis. Using a recently developed free light chain (FLC) immunoassay, it ...
In addition, the ratio of S1P/HDL was found to increase in patients with stable coronary artery disease and following myocardial infarction22. Psoriasis patients have been reported to have lower levels of HDL23. However, in the current study, HDL levels in the subset of patients with severe ...
Among SAD patients, 28.4% had raised total FLC (from 12% in RA to 30% in SLE and APS) with a normal kappa/lambda ratio. Total FLC levels were significantly higher in SAD with inflammation, active disease in SLE and SjS, and an impaired pulmonary functional capacity in SSc, while ...
High sensitivi- ty and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis. J Neuroimmunol 2014; 276:175-9 (PMID: 25146968).G. Hassan-Smith, L. Durant, A. Tsentemeidou, L.K. Assi, J.M. Faint, S. Kalra, M.R. Douglas, S.J. Curnow, ...