Elevated Serum Beta-Hydroxybutyrate Levels (B-hb) in Patients with Type 2 Diabetes Mellitus Using Sodium-Glucose Cotransporter 2 (SGLT-2) InhibitorSimant Thapa
We found elevated levels of betahydroxybutyrate (BHB) in serum and whole-blood (WB) of prolactinomas (0.481±0.211/0.329±0.228mM in serum/WB), but it was statistically significant (p≤0.0033, Bonferroni correction) only in serum when compared with LH/FSH-secreting tumor patients (0.269±0.139...
Among them, only beta-hydroxybutyrate (BHB) was elevated in CRC. Here, we first confirm the increased level of beta-hydroxybutyrate by targeted metabolomic analysis using an independent cohort of 400 serum samples by UPLC-QQQ-MS/MS analysis. Using appropriate cell and animal models, we find ...