Genetically engineered mice (GEM)We generated human EGFRL858R/T790M/C797Stransgenic mice.They can help in drug development to overcome C797S-mediated osimertinib resistance.Such knock-in systems for oncogenic proteins can help develop other targeted agents....
c RT-qPCR analysis of Fut family mRNA expression in hepatocytes of ICR4R+ mice infected with HCV (1 ×106 copies per mouse) in vivo for 40 d (n = 3 mice per group per study). The figure is created with Biorender.com. d Immunoblot analysis of FUT8 in lysates of Huh7 cells ...
该研究揭示了UDP-Glc抑制肿瘤的新功能,建立了代谢小分子调控蛋白质功能的新模式,建立了细胞代谢与RNA稳定性调控的新连接,为肺癌转移的诊断和治疗提供了首个生化标志物及干预新策略。 ☆Science (IF=41.03):The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice.(2019 Jun 21) 糖基化改变是组织...
Low concentration of cadmium chloride (2.5 mu M) was applied to mice primary lung epithelial cells and cell proliferation was measured both by cell cycle analysis and Brdu incorporation assay. Effects of differential dose of cadmium chloride on lung epithelial cells were evaluated morphologically by ...
^(131)I-anti EGFR-BSA-PCL suppressed the development of xenografted colorectal cancer in nude mice, thereby providing a novel candidate for receptor-... W Li,YH Ji,CX Li,... - 《世界胃肠病学杂志(英文版)》 被引量: 0发表: 2016年 Discovery and validation of podocalyxin-like protein as ...
There after 1 × 106 HEK293T cells were injected subcutaneously into the left and right flanks of the mice. Once the tumors became visible, the tumor size was measured every 3 to 4 days using micrometer calipers. Tumor volumes were calculated using the following formula: volume = 0.5 ...
Human patient-derived xenografts (PDXs) were grown in immunodeficient mice and treated with a set of EGFRi; the EGFRi erlotinib was selected for more expansive in vivo studies. Single-cell RNA sequencing was performed on mammary tumors from the basal-like PDX WHIM2 that was treated with ...
Animals Mice Endoplasmic Reticulum Fibroblasts Arabidopsis Calcium Calreticulin Tunicamycin Phylogeny Protein Folding DOI: 10.1093/pcp/pcn065 年份: 2008 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ProQuest EBSCO leaddiscovery.co.uk 相似文献 参考文献...
展开 关键词: Animals Humans Mice Carcinoma, Non-Small-Cell Lung Lung Neoplasms Quinazolines Transcription Factors MicroRNAs Receptor, Epidermal Growth Factor src-Family Kinases DOI: 10.1172/JCI73048 被引量: 78 年份: 2014 收藏 引用 批量引用 报错 分享 全部...
1 million cells were injected per site, subcutaneously, into age-matched male or female NOD-scid IL2Rgammanull (NSG) mice (InVivos). Water supply was supplemented with 2 mg/ml doxycycline (Sigma, D9891). Mice were sacrificed at 4 weeks latency (with individual tumors not exceeding 1.5...