However, it can be difficult to obtain sufficient lung tumor tissue for testing. In such cases, a new blood test can be used instead, suggest the results from a "real world" study presented last week at the 2015 European Lung Cancer Conf...
Cobas EGFR Mutation Test v2, a blood-based companion diagnostic for cancer drug Tarceva, is the first FDA-approved genetic test that can detect epidermal growth factor receptor (EGFR) gene mutations which are present in about 10-20 percent of NSCLC...
The normal range for EGFR (epidermal growth factor receptor) in the blood is between 100-400 ng/mL. However, the normal range can vary slightly depending on the laboratory performing the test. It is important to note that EGFR levels can be affected bya variety of factors, including age, ...
Clinical utility of a blood-based EGFR mutation test in patients receiving first-line erlotinib therapy in the ENSURE, FASTACT-2, and ASPIRATION studiesBlood-based testingCobas assayEGFR mutationErlotinibObjective: Patients with advanced non-small-cell lung cancer (NSCLC) with an adenocarcinoma ...
An eGFR test can also be used to monitor kidney function if you are taking a medication that has the potential to damage the kidneys. What does the test measure? It calculates the GFR, which reflects how well the kidneys filter the blood and is represented in milliliters per minute (mL/...
“The blood test only has a sensitivity of 70% or 80% so there are false negatives. In other words, if you have a negative result in the blood test it may be that the mutation was present but not detected.” Oxnard led an analysis that looked exclusively at data from the phase I ...
First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months...
KitDxS EGFR Mutation Test Kit (DxS,Manchester, UK)48.2%95.4%90.0%68.1%73.5%Jie Wang2744YesPlasmaQIAamp DNA Mini KitDHPLC68.4%83.4%70.0%82.3%80.0%Britta Weber3196NoPlasmacobas DNA Sample Preperation KitARMS cobas EGFR Blood Test60.7%96.4%73.9%93.5%91.3%NCT012039174652YesPlasmaQIAamp Circulatin ...
(also called aliquid biopsy) is generally not preferred. However, in situations where insufficient tumor cells are available for molecular testing from a tissue biopsy, or in situations where a tissue biopsy is not able to be taken, a blood test (liquid biopsy) may be an acceptable ...
(TKIs) treatment in non- small cell lung cancer (NSCLC) patients. The objective of this study was to determine the feasibility and predictive utility of EGFR mutation detection in peripheral blood. METHODS: Plasma, serum and tumor tissue samples from 164 NSCLC patients were assessed for EGFR ...