Here, the results of a phase 1/2 single-arm trial (NCT03744026) assessing the safety and efficacy of blood-brain barrier (BBB) disruption with an implantable ultrasound system in recurrent glioblastoma patients receiving carboplatin are reported. A nine-emitter ultrasound implant was placed at the...
CCH, Changhua Christian Hospital; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; SMBG, self-monitoring of blood glucose. Full size image Data collection Data were collected from the hospital’s electronic medical record systems, including the DCMP diabetes registry, prescriptions, ...
144,145 Inhibition of the activity of these receptors results in the suppression of downstream oncogenic signaling cascades including those engaging mitogen-activated protein kinase and phosphatidylinositol-3-kinase.146 Dp strongly inhibited the protein tyrosine kinase activity of all tested RTKs (EGFR, ...
Results Whole blood transcriptomes reveal diversity of COVID-19 patients not explained by disease severity To investigate the host immune response of COVID-19 patients in a systematic approach, whole blood transcriptomes were analyzed from 39 patients and 10 control donors recruited at the same hospit...
Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded RBF MRI measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, ...
Results The BpTRU systolic (± SD) reading (117.3 ± 14.1 mmHg) was significantly lower than the routine clinic mean systolic blood pressure (143.8 ± 15.5 mmHg; P < 0.001) and the repeat blood pressure taken with a DINAMAP PRO400 monitor in a quiet room (129.9 ±...
CKD was defined as ACR ≥30 mg/g or eGFR <60 mL/min/1.73 m2. Results: The mean SDdn of systolic BP (SBP) was 10.2 ± 0.2 and 9.1 ± 0.1 mmHg and the mean ARV of SBP was 9.2 ± 0.2 and 8.6 ± 0.1 mmHg for those with and without CKD, respectively (each p ≤ 0.001). ...
We also considered hsa-miR-148a, which has an obvious fold change, but filtered by statistics test, and was proven highly important in previous studies. Subsequently, we used scatter plot to represent the relative expression levels of these nine miRNAs (Figure 3). The qRT-PCR results were ...
Both technical and biological factors can affect the concordance between tumour and plasma, generating false-negative and false-positive results in ctDNA analysis. False-negative results might be explained by the low volume of plasma yielded (4–5 ml) from a typical blood sample of 10 ml,...
Nearly half of colocalizing QTLs are probably explained by splice variation (17 of 42 (40.5%) had an sQTL PIP > 0.9, in contrast to 20.2% for mRNA-specific QTLs and 6.4% for protein-specific QTLs; Fisher’s exact test P = 5.3 × 10−3 and 5.3 × 10−8;...