In parallel, candidalysin also activated the EGFR-ERK pathway in a ligand-dependent manner, resulting in c-Fos activation and release of the neutrophil-activating chemokines G-CSF and GM-CSF. In mice, early clearance events of oral C. albicans infection required p38 but not...
图1.3 EGFR通过EGF配体激活形成二聚体流程示意图[10] EGFR受体可激活三个信号通路[11]:参与免疫调节的JAK/STAT信号通路,参与细胞增殖的RAS-RAF-MEK途径(MAPK/ERK通路),以及参与细胞存活的PI3K-AKT-mTOR途径(图1.4)。RAS-RAF-MEK途径负责控制基因转录活动和细胞循环周期,而PI3K-AKT-mT0R途径可激活抗细胞凋亡的信号。
(2017) Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFR-ERK pathway. Oncogene 36, 6691-6700.Ding D,Huang H,Jiang W,et al.Reticulocalbin-2 enhances hepatocellular carcinoma proliferation via modulating the EGFRERK pathway[J].Oncogene,2017 Jul 24.doi:10.1038/...
如下图所示,细胞表皮生长因子受体(EGFR)和血管内皮生长因子受体(VEGFR)具有共同的下游信号传导,以PI3K/AKT/mTOR和RAS/RAF/ERK为代表,这两条信号通路与血管生成、细胞增殖、生长、转移和粘附相关,在肿瘤形成中发挥着相互独立、但又互为补充的作用。 图:细胞内的EGFR和VEGFR...
Fig. 5: EGFR-ERK pathway activates GRHL1 and promotes its nuclear translocation. ApGL3-enhancer vector containing RAD21 promoter fragment was transfected into A549-control cells and A549-shGRHL1 cells, co-transfected with Renilla control plasmid. After serum-free treatment for 12 h, EGF (100...
EGFR是一种跨膜酪氨酸激酶受体,在配体结合时被激活。EGFR介导的信号传导涉及两个主要的细胞内级联,KRAS-MAPK传导和KRAS-PI3K传导。KRAS突变会导致KRAS蛋白的组成型激活,KRAS蛋白充当分子开关,持续刺激下游信号通路RAF-MEK-ERK 和PI3K-AKT...
ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. EGFR activation signals multiple downstream signaling cascades such as the Ras - ERK, PI3-K...
EGFR/SRC/ERK signaling sustains YTHDF2 expression To determine which signaling pathway drives the upregulation of YTHDF2 in GBM, the most commonly aberrantly activated pathways that include AKT, FGFR, PDGFRα/β, WNT, TGFβR1, EGFR, SRC, and ERK1/2 were tested by using inhibitors MK-2206...
The MEK/ERK pathway is involved in the phosphorylation at Ser732 associated with polymerized MTs. (a) Me#28 cells treated with UO126 or Y27632 inhibitors for 24 h. Upper panel: western blotting performed on lysates from untreated or treated cells. Bottom panel: densitometric analysis of the...
EGFR monoclonal antibody could partially reverse multiple drug resistance as a result of serum starvation. Conclusion Serum starvation may induce drug resistance in gastric cancer cell and the mechanism may be related to the activation of EGFR / ERK signaling pathway. 展开 ...