The gene alterations of the three PDXs were listed in Supplementary Table 4, note that the alterations in PDX-1R and PDX-2R were numerous due to the lack of gene mutation spectrum of paired normal tissue or blood to eliminate the redundant information of gene alterations. Even so, there ...
Creatinine serum level augmentation of as little as 0.3 mg/dL could correspond to a great decrease in GFR, so that creatinine serum levels in the normal range or with minor changes could mask sever GFR alteration. Consequently, measuring and reporting both eGFR and creatinine serum level ...
Copy number variants were estimated using the BICSeq algorithm61 and the read coverage data of tumour versus normal pairs. We inferred ploidy using the B allele frequencies of heterozygous germline variants. For low coverage WGS without matching blood data we used as a proxy an electronic pool ...
“Amplifying,”“amplification,” and grammatical equivalents thereof refers to any method by which at least a part of a target nucleic acid sequence is reproduced in a template-dependent manner, including without limitation, a broad range of techniques for amplifying nucleic acid sequences, either ...
LncRNAs are novel subsets of noncoding RNAs, which regulate a variety of biological responses via a diverse range of mechanisms. Recent studies have shown that numerous changes in the expression of lncRNAs occur during the activation of the innate immune response and T-cell development, ...
LncRNAs are novel subsets of noncoding RNAs, which regulate a variety of biological responses via a diverse range of mechanisms. Recent studies have shown that numerous changes in the expression of lncRNAs occur during the activation of the innate immune response and T-cell development, differentiati...
(FFPE) for the ultrasensitiveEGFR-Thr790Met mutation testing. Of these, 34 met the eligibility criteria for inclusion in the pretreatment cohort: (1) diagnosed with advanced NSCLC and (2) treated in first line with first- or second-generation EGFR-TKI. A flow chart of patient enrollment is ...
(Figure 2). Further analysis found that in the smoking subgroup, the OR value of SUVmaxand EGFR mutation was 0.947 (95%CI: 0.909–0.986;p= 0.008). In the normal CEA subgroup, the OR value of SUVmaxand EGFR mutation was 0.939 (95%CI: 0.906–0.973;p< 0.001). The characteristics of ...