Overexpression of EGFR can lead to uncontrolled cell growth and division, which can contribute to cancer development. 中文回答: EGFR(表皮生长因子受体)在血液中的正常值范围为100-400 ng/mL。然而,正常值范围可能因执行检测的实验室而略有不同。需要注意的是,EGFR水平可能受多种因素的影响,包括年龄、性别和...
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) and EGFR-TKI combination treatments have become the standard first-line treatments for EGFR-mutated non-small cell lung cancer (NSCLC) patients. However, the best option has yet to be determined. This study compares the effi...
New EGFR mutation tests such as real-time polymerase chain reaction (RT-PCR), amplification refractory mutation system (ARMS), peptide nucleic acid (PNA)-based PCR, and droplet digital PCR (dd-PCR) provide reliable, quick test results with high sensitivity (limit of detection: 0.01%–1%) and...
Tagrisso is now recommended as a first-line treatment for EGFR mutations because it's best able to penetrate into the cerebrospinal fluid and pass through the blood-brain barrier to help fightlung cancer with brain metastases—particularly important because lung cancer often spreads to the brain.13...
The effects of CD109 expression were examined on migration, cell proliferation, spheroid formation and soft-agar colony-formation assay. Meanwhile, cervical cancer cell lines with high CD109 expression were chosen for the functional study using siRNA knockdown and CRISPR/Cas9 knockout. Results IHC ...
Studies over the past several years have identified the EGFR signaling pathway as one of the major modulators of bone metabolism, regulating the proliferation and differentiation of osteoblasts and chondrocytes, osteoclastogenesis, and cancer metastasis to bone (11). We previously demonstrated that ...
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20–30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive growth of
Lung cancer is notorious for its high morbidity and mortality rate worldwide [1], in which non‐small cell lung cancer (NSCLC) accounts for 80%‐85% of the incidences [2]. In the NSCLC population, epidermal growth factor receptor (EGFR) gene is found in 10–20% of Caucasians and at ...
The test is specific and sensitive (detection of 10 cancer cells/ml blood), and only minimally invasive. Positivity is statistically correlated to high grade neuroendocrine carcinomas and to a poor prognosis with a 3-fold higher lethal risk. The test now needs to be assessed for its usefulness...
However, the molecular mechanism underlying the high expression and oncogenic roles of PELI1 in cancers remains limited. Herein, we revealed a novel regulation mechanism by which PELI1 and EGFR cooperate to promote breast cancer metastasis. EGFR is positively correlated with PELI1 expression in ...