4、A Mini KitDxS EGFR Mutation Test Kit (DxS,Manchester, UK)48.2%95.4%90.0%68.1%73.5%Jie Wang2744YesPlasmaQIAamp DNA Mini KitDHPLC68.4%83.4%70.0%82.3%80.0%Britta Weber3196NoPlasmacobas DNA Sample Preperation KitARMS cobas EGFR Blood Test60.7%96.4%73.9%93.5%91.3%NCT012039174652YesPlasmaQIAamp ...
progressed after osimertinib [93]. In our NMA, lazertinib plus amivantamab ranked second and is one of the only two treatments that prolonged progression-free survival compared to third-generation EGFR-TKIs. Like osimertinib plus chemotherapy, we also found that lazertinib plus amivantamab did ...
After the participants sat quietly for at least 5 min, blood pressure measurement was completed with an electronic blood pressure monitor (GB3053–93) of the nondominant arm three times every minute to obtain the mean. Laboratory examinations After a fasting period of more than 10 h, blood (...
34,35to create predictive models forEGFRandKRAS33. In the current work, we apply a more robust approach based on multiple splits to define the train and test sets, preventing an eventual bias from specific patients and effectively assessing the variance in the data. Additionally, this study ai...
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis
Molecular testing in non–small cell lung cancer (NSCLC) is commonly limited by inadequate tumor sample. Plasma cell-free DNA (cfDNA) genotyping as a complementary test is specific but only moderately sensitive. Genotyping of cfDNA in pleural and pericardial effusion (PE-cfDNA) can further optimize...
Despite epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer (NSCLC), acquired resistance inevitably develops, limiting clinical efficacy. We found
Non-standard blood pressure (BP) is a factor in 15% to 20% of dementia cases encountered by the age of 80. Dementia's connection to hypertension remained apparent until the age of seventy-five. The regulation of blood pressure from midlife to the beginning of late-life could potentially ...
Laboratory data, evaluated at hospital admission included: complete blood count (CBC); prothrombin time (PT) expressed as the international normalized ratio (INR); activated partial thromboplastin time (aPTT); D-dimer value; fibrinogen; transaminases; total bilirubin; lactate dehydrogenase (LDH); C-...
All patients had EGFR 20ins documented by local testing at enrollment, 143 of whom (95.3%) were further confirmed by central testing on tumor tissue samples (n = 143) and/or paired peripheral blood samples (n = 117). A total of 38 distinct EGFR 20ins variants were identified (...