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Pancreatic beta cell mass is dynamically regulated in response to increased physiological and pathological demands. Understanding the mechanisms that contr
p53. Cells were treated withJEGFRi or EGFRi+mTORi andKinducible expression of shControl or shEGFR and/or shmTORn = 4 independent replicates. Error bars denote Mean ± SEM.p < 0.0001 for DBD untreated vs DBD EGFRi/DBD shEGFR and TAD untreated vs TAD EGFRi+mTORi/shEGFR+s...
Therefore it is not surprising that dozens of monoclonal antibodies (mAbs) and small-molecule tyrosine kinase inhibitors (TKIs) have been designed and developed over the past few decades and a few of them are being used in clinical targeted therapies [23,31]. Compared with traditional ...
Cell movement must not be continuous and therefore gross velocity depends on at least two parameters: the fraction of an observation period in which the cells do not move (migration probability, Pm) and the mean net velocity obtained from the periods when the cells are moving (Supplementary Fig...
The ATLANTIC trial reported that higher PD-L1 expression in tumors was involved in a higher objective response in patients with EGFR+/ALK+ non-small cell lung cancer (NSCLC), indicating the possibility of anti-PD-1/PD-L1 therapy as a third-line (or later
overexpressing (HC2 20d2/c) cell lines MFI Antibody HN5 HC220d2/c Control ICR10 ICR16 6.87 1092.45 1189.75 5.04 3.55 593.05 Abbreviations: EGFR ¼ epidermal growth factor receptor; EGFRvIII ¼ type-III deletion mutant form of EGFR; mAbs ¼ monoclonal antibodies; MFI ¼ mean fluorescence...
What does the test result mean? If an individual’s lung cancer has an sensitizingEGFRmutation, then an EGFR-targeted tyrosine kinase inhibitor (TKI) may be effective in treating the tumor. If no sensitizing mutation is detected by theEGFRtest, then the tumor is less likely to respond to TK...
Although Grb2 does not contribute directly to EGFR ubiquitination, Cbl binding to EGFR and receptor ubiquitination decrease dramatically when Grb2 cannot bind the receptor. Indeed, one clear prediction of the model is that if ubiquitination were to require only one pY, it would not show a ...
Data represent mean plasma concentration (±s.d. when n > 3 NHP treated) for the NHPs treated at each dose within one single experiment. d,e, Activation of circulating CD4+ T cells (d) and CD8+ T cells (e) 24 h after drug administration (HER2-XPAT protein, n = 16 ...