MAP激酶磷酸化转录因子，如激活蛋白1（AP-1;Fos-Jun二聚体）和Elk-1，导致细胞生长和发育。EGFR对Janus激酶(JAK)的磷酸化导致转录蛋白信号换能器和激活器(STATs)的激活，最终导致细胞的生长和分化。EGF信号的另一个关键方面涉及磷脂酶c - γ1 (PLCγ1)，它将PIP2裂解为IP3和DAG。IP3的产生导致内质网钙的释放...
MAP激酶磷酸化转录因子,如激活蛋白1(AP-1;Fos-Jun二聚体)和Elk-1,导致细胞生长和发育。EGFR对Janus激酶(JAK)的磷酸化导致转录蛋白信号换能器和激活器(STATs)的激活,最终导致细胞的生长和分化。EGF信号的另一个关键方面涉及磷脂酶c - γ1 (PLCγ1),它将PIP2裂解为IP3和DAG。IP3的产生导致内质网钙的释放,而...
Anti-Human EGF Receptor specific antibody was purified by affinity chromatography and then biotinylated. Immunogen: CHO cells derived Recombinant Human EGF Receptor (EGFR) (PeproTech catalog# 100-15R) Sandwich ELISA: To detect Human EGF Receptor by sandwich ELISA (using 100 μl/well antibody ...
MAP激酶磷酸化转录因子,如激活蛋白1(AP-1;Fos-Jun二聚体)和Elk-1,导致细胞生长和发育。EGFR对Janus激酶(JAK)的磷酸化导致转录蛋白信号换能器和激活器(STATs)的激活,最终导致细胞的生长和分化。EGF信号的另一个关键方面涉及磷脂酶c - γ1 (PLCγ1),它将PIP2裂解为IP3和DAG。IP3的产生导致内质网钙的释放,而...
Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter & Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and...
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of ...
EGF's help encourage cell growth by binding with a receptor known as EGFR. This is the key thing that epidermal growth factor is known to interact with.
The different EGFR signaling pathways activation depends on the type of ligand and on its binding affinity to the receptor, which can lead to the formation of stable or weak homodimers and of heterodimers with the other ErbB receptors. EGF, TGF-α, HB-EGF, and BTC are high-affinity ligands...
When EGF binds to its receptor (EGFR), it activates intracellular signaling pathways that lead to DNA synthesis and cell proliferation. EGF is naturally present in various tissues and body fluids, including saliva, urine, and milk. It is primarily synthesized in the submandibular glands and ...
As a mitogen, EGF initially binds with high affinity to specific cell surface receptors, inducing their dimerization, which is crucial for activating the receptor's cytoplasmic tyrosine kinase domain. This, in turn, initiates signal transduction, leading to DNA synthesis and cell proliferation. ...