Protocols and Documentation Applications Resources and Publications Related Products Overview Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter & Cohen). EGF promotes EGFR dimerization, resulting in...
Epidermal growth factor (EGF) is characterized by high affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter & Cohen). EGF promotes EGFR dimerization, resulting in activation of downstream pathways including PI3K, ERK1/2, JAK/STAT, β-catenin, and...
The different EGFR signaling pathways activation depends on the type of ligand and on its binding affinity to the receptor, which can lead to the formation of stable or weak homodimers and of heterodimers with the other ErbB receptors. EGF, TGF-α, HB-EGF, and BTC are high-affinity ligands...
We hypothesized this would correlate with stronger EGF receptor (EGFR) binding affinity and used histology to further quantify the improvement in wound healing. Methods Biochemical testing of EGFs was done in mouse and human cell lines to ensure mouse wound healing experiments would reflect human ...
The chapter describes the EGFR that is the high-affinity receptor for epidermal growth factor (EGF), transforming growth factor-a (TGFa), and VGF. Activated EGFRs stimulate the proliferation of numerous cell types in vitro and epithelial cells in vivo. Binding of the corresponding ligand induces...
The different EGFR signaling pathways activation depends on the type of ligand and on its binding affinity to the receptor, which can lead to the formation of stable or weak homodimers and of heterodimers with the other ErbB receptors. EGF, TGF-α, HB-EGF, and BTC are high-affinity ligands...
EGF's help encourage cell growth by binding with a receptor known as EGFR. This is the key thing that epidermal growth factor is known to interact with.
Publications All (1) KD/KO (1) SpeciesApplicationTitle human Br J Cancer Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer. Authors - X Wang KD Validated View ArticleProteintech North America (HQ) Proteintech Group, Inc 5500 Pearl Street, Suite ...
Western blot analysis of extracts from control Hela cells (lane 1), or EGFR knockout Hela cells (lane 2) using EGF Receptor Antibody #2232, (upper) or #8457 β-Actin (D6A8) Rabbit mAb (lower). The absence of signal in EGFR-knockout Hela cells confirms specificity of the antibody for...
EGF is a high affinity ligand of the EGF receptor (ErbB). Four ErbB (HER) family receptor tyrosine kinases including EGFR/ErbB1, ErbB2, ErbB3 and ErbB4, mediate responses to EGF family members[2]. EGF binding induces dimerization of the EGF receptor resulting in activation of the protein ...