2024: Alpha-2 antagonists should be developed as xylazine antidotes in humans Regional Anesthesia and Pain Medicine 2024 Gokalp, E.; Gurgoze, S.; Altan, S. 2020: Effects of xylazine-ketamine, xylazine-propofol and xylazine-ketamine-propofol administration on free radical generation and blood gases...
TBI in humans [28] due to its ability to replicate the mechanical aspects of brain injury and the subsequent pathophysiological processes, including inflammation. Our choice of the CCI model is reinforced by our prior studies, wherein we successfully demonstrated the efficacy of intranasally administe...
Anesthesia was induced through an intramuscular injection of 50 mg/kg zolazepam and tiletamine (Zoletil 50; Virbac, Carros, France) and 10 mg/kg xylazine (Rompun; Bayer HealthCare, Leverkusen, Germany). IRE was then performed in the mice using the corresponding voltages. The electrodes were ...
Mice were anesthetised using 100 mg kg − 1 Ketamine and 10 mg kg − 1 Xylazine, and blood was collected into heparinised pediatric tubes (Kabe Labortechnik GmbH, Numbrecht, Germany) using the retro-orbital route, followed by heart removal. Heparinised whole-blood samples were ...
XylazineSeveral anesthetics are known to cause respiratory and cardiovascular depression in humans and animals; but, these diverse effects have not been extensively investigated in laboratory rodents. The objective of this study is to choose a suitable anesthetic combination for use in surgical models ...
For behavioral testing, all rats were implanted with a guide cannula (26 gauge cannula; Plastics One, Roanoke, VA) allowing brain drug injections targeting the lateral ventricle (LV) or DR under ketamine/xylazine anesthesia. The cannulas were positioned and attached to the skull with dental acryl...
On day 28 of gestation, sows were injected intravenously with compound xylazine (20 μL/kg body weight) and then bled. Slaughter was carried out after the sows had no heartbeat. The uterus and ovaries were removed from each sow immediately after slaughter. Conception rate was calculated as ...
While similar neurotoxicity has not been definitively shown in humans, the wealth of animal research on damaging properties suggests that the chemical is not a safe drug for human consumption.Hidden Risks and Contaminants:Other drugs chemically similar to ecstasy, such as MDA (methylenedioxyamphetamine...
Before laser-induced thrombosis and blood collection, all mice were anesthetized with a single injection of ketamine and xylazine mixture (120 mg/kg, i.p., Ketamina 10%, Biowet, Poland; 12.5 mg/kg, i.p., Xylapan, Biowet, Poland). After the experiments, the mice were euthanized ...
After completion of experimental period, rats were slaughtered under mild anesthesia by 60 mg/kg of ketamine and 6 mg/kg of xylazine. Blood samples were taken and plasma was separated by centrifugation at 322 g for 20 min and preserved at −20 °C for hormonal analysis. The testicular ...