Here, we show that peripheral frequency of a regulatory T cell population, characterized by the coexpression of CD3 and CD56 molecules (T), is reduced in individuals with new-onset type 1 diabetes (T1D). In three independent T1D cohorts, we find that low frequency of circulating Tcells is...
Effector functions of the γδ T cell subsets develop under the influence of innate programming and environmental signals. Programming during thymocyte maturation restricts the functional potential of populations of γδ T cells expressing given T cell receptors (TCRs) but they retain some degree of ...
During T cell development, hematopoietic stem cell-derived NK/T precursors generate thymocytes that mature in the thymus through double negative (DN), double positive (DP) and single positive (SP) phases defined by CD4/CD8 coreceptor expression. Pre-TCR and TCRαβ expression constitute checkpoint...
addition, we show that Blimp1 controls common and unique aspects of Treg and Teff cell function by differentially regulating gene expression in these T cell subsets. These findings document previously unappreciated aspects of Blimp1’s role in T cell biology and shed light on the intricate mechanis...
Keywords: tumor-infiltrating lymphocytes, chromatin remodeling, T cells, acetate, acetyl-CoA synthetase, T cell exhaustion, T cell hyporesponsiveness, tumor immunity, effector functions 展开 关键词: T cell exhaustion T cell hyporesponsiveness T cells acetate acetyl-CoA synthetase chromatin remodeling ...
Notably, blocking the action of the T(eff) cell-derived IL-10 results in enhanced pulmonary inflammation and lethal injury. Our results show that antiviral T(eff) cells exert regulatory functions--that is, they fine-tune the extent of lung inflammation and injury associated with influenza ...
Whether and, if so, how Mg2+ availability in tissues is sensed and integrated functionally by CD8+ T cells has not been investigated. Results First, we explored how Mg2+ affected memory CD8+ T cell function in vitro, using complete media containing 1.2 mM Mg2+ versus no Mg2+ as the only...
activated T cells require for proliferation and effector functions.11 Although it has been shown that upon T cell activation, T cells shift from OXPHOS to aerobic glycolysis, this does not mean that OXPHOS is completely stopped. Along with glucose, glutamine is also taken into T cells upon ...
Fig. 4: T-cell effector functions are inhibited at acidic pH. aInterferon γ (IFNγ) production from C57BL/6 (B6) T-cells is reduced at low pHe, as determined by ELISA;n = 3,p = 0.00013.bINFγ production, measured over a range of pHe in T-cells from B6 mice as well ...
Recent work shows that after stimulation with antigen, CD4+ and CD8+ T cells embark on a programme of proliferation that is closely linked with the acquisition of effector functions and leads ultimately to memory-cell formation. Here, we discuss the signals required for commitment to this programm...