The Mouse Naive/Effector/Memory T Cell Markers Flow Cytometry Panel can be used to distinguish naive, effector, and memory mouse T cells in both CD4 and CD8 T cell populations.T cells are identified by expression of CD3. There are two major subsets of conventional T...
effector memory T cellsBackground— Adaptive T-cell response is promoted during atherogenesis and results in the differentiation of nave CD4+T cells to effector and/or memory cells of specialized T-cell subsets. Aim of this work was to investigate the relationship between circulating CD4+T-cell ...
We previously reported that donor CD4+ effector memory T cells (TEMs) do not cause GVHD but transfer functional T-cell memory. In the present work, we demonstrate in an MHC-mismatched model that CD4+ TEMs (unprimed to recipient antigens) mediate GVL against clinically relevant mouse models ...
terminallydifferentiatedmemoryTcells,butwere distinctfromcentralmemory,exhausted,andsenescentT cells.Despitetheirphenotypicmarkersofterminal differentiation,Th17cellsmediatedandpromotedlong- termanti-tumorimmunityininvivoadoptivetransfer experiments.Furthermore,Th17cellshadahighcapacity ...
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>5 T cells. In intra-tumoural T cells, dominant clonotypes were concentrated within effector (CD8 TEM, CD8 TEMRA) and ‘antigen-experienced’ T cell clusters (CD8 TEX, CD4 CXCL13; Fig.2c), while non-dominant clonotypes were mostly found in naive, memory or regulatory T cell subtypes...
CD4+memory T cells; no induction or boosting of SIV Env-specific antibodies; and induction and then loss of T-cell responses to an SIV protein (Vif) not included in the RhCMV vectors. Protection correlated with the magnitude of the peak SIV-specific CD8+T-cell responses in the vaccine ...
et al. Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of t-bet transcription factor. Immunity 27, 281–295 (2007). Article CAS Google Scholar Martin, M. D. & Badovinac, V. P. Defining memory CD8+ T cell. Front. Immunol. ...
CD4T cells lacking the costimulatory molecule CD28 have been described both in elderly individuals and in chronic inflammatory disorders, one being rheumatoid arthritis (RA). We, in this study, provide a comprehensive characterization of cell surface markers on and function of such CD28CD4T cells, ...
Long-term control of viral replication relies on the efficient differentiation of memory T cells into effector T cells during secondary immune responses. Recent findings have identified T cell precursors for both memory and exhausted T cells, suggesting