T-cell infiltrates are not only found within the parenchyma and the meninges, but also in the cerebrospinal fluid (CSF) that bathes the entire CNS tissue. How the T cells reach the CSF, their functionality, and whether they traffic between the CSF and other CNS compartments remains ...
Once activated, antigen-experienced effectorT cells(both cytotoxic and helper variants) respond more efficiently to antigen receptor stimulation and gain the capacity to traffic to multiple tissues in the body. The reasons for this are several-fold: ...
Polystyrene ELISA or cell culture plates should not be used. After I finish the staining process, how long can I wait before reading my LEGENDplex™ samples? The samples can be kept overnight at 4°C while being protected from exposure to light and be read the next day. There...
The aim oftumor immunotherapyis to harness and potentially to enhance the recognition and destruction of tumor cells through the production ofeffector cellsthat can traffic to sites of active tumor growth and mediate tumor rejection. Although the role ofhumoral immunity(e.g., antibody production) in...
Suzuki, K. et al. Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin.Nature446, 680–684 (2007). ArticleCASPubMedGoogle Scholar Holmes, S. et al. Sema7A is a potent monocyte stimulator.Scand. J. Immunol.56, 270–275 (2002). ...
In the presence of apical CXCL12 and after additional E-30 infection all T cell subpopulations displayed significant higher migration rates compared with the uninfected control conditions (Fig. 2b, d, f and Fig. 3c–d). When CXCL12 was present on the apical side of HIBCPP cells, the migrati...
The arbuscule is a fungal structure surrounded by a periarbuscular matrix and bordered by a carbohydrate-rich periarbuscular membrane towards the living host cell (Balestrini & Bonfante, 2014). Here, we report a structural model-based classification of all predicted secreted proteins of the AM ...
CD4+ CD25+ forkhead box P3 (FoxP3)+ regulatory T cells (T reg cells) are known to suppress adaptive immune responses, key control tolerance and autoimmunity. We challenged the role of CD4+ T reg cells in suppressing established CD8+ T effector cell respo
Int. Angiol.27 Google Scholar +T cells control the differentiation of Gr1+monocytes into fibrocytes.106, 17892–17897 (2009). PubMedGoogle Scholar 103 FASEB J.15 56 ArticleCAS Google Scholar Nature Rev. Rheumatol.5 We wish to thank E. Tarquino for excellent help with manuscript preparation. ...
cell activation by decreasing the time of commitment and by protecting T cells from death. These findings explain in quantitative terms the essential requirement for professional APCs in T cell priming and show that the duration of antigenic stimulation is the major factor determining the fate of ...