Using killer cell lectin-like receptor G1 as a marker to distinguish these effector subsets, we found that despite their diverse cell fates, both subsets possessed remarkably similar gene expression profiles and functioned as equally potent killer cells. However, only t...
Genome-wide transcriptomics analysis of IFNγ-producing or IL-17A-producing γδ T cell subpopulations reveals marked differences in their mode of activation and functional potential in the periphery. We describe the differential expression of a set of 2
Define Effector cell. Effector cell synonyms, Effector cell pronunciation, Effector cell translation, English dictionary definition of Effector cell. n. 1. A muscle, gland, or organ capable of responding to a stimulus, especially a nerve impulse. 2. A ne
Helper T-cell subsets and control of the inflammatory response Effector cell phenotypes Teffector cellsare those that promote inflammatory processes through the release of cytokines (Fig. 16.2). These cells function by modifying or promoting the activity ofaccessory cellsthat ultimately mediate the infla...
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The Mouse Naive/Effector/Memory T Cell Markers Flow Cytometry Panel can be used to distinguish naive, effector, and memory mouse T cells in both CD4 and CD8 T cell populations.T cells are identified by expression of CD3. There are two major subsets of conventional T...
[2,10]. T cell subsets contribute either effector or regulatory functions that are maintained during homeostatic conditions to maintain immunological tolerance. However, in pathological states, effector T cell (Teff) subsets react against misfolded and disease-specific self-proteins that can break ...
While these effector T cell subsets produce proinflammatory cytokines, which cause substantial tissue injury in vivo in CD, recent studies have suggested the existence of additional CD4+ T cell subsets with suppressor functions. These subsets include type 1 regulatory T cells and CD25+CD4+ regulatory...
accompanied by the expression of a variety of inhibitory receptors. This state is known as CD8+T cell“exhaustion” and often leads to the loss of control and progression of tumors. Recent studies provided us a better understanding of the mechanisms of T cell exhaustion, this review provides an...
There is accumulating evidence from mouse models that specific environments such as inflammation or non-lymphoid tissues can induce further differentiation/adaptation into specialized activated Treg cell subsets, also referred to as effector (e)Treg cells3,4 (reviewed in ref. 5). Characteristic for eT...